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Tay-Sachs disease (TSD) is an inborn error of metabolism that results in death, often in early...

Tay-Sachs disease (TSD) is an inborn error of metabolism that results in death, often in early
childhood. A phenotypically normal couple is considering having a child. The male had a female
first cousin on his father’s side that died from TSD. The female had a maternal uncle with TSD.
There are no other known cases in either of the families and none of the matings has been
between related individuals. Assume this trait is very rare.
a. Draw a pedigree showing the relevant individuals. Using defined symbols, show the
genotypes of the relevant individuals.
b. Calculate the probability that the male and female in question are carriers for TSD.
c. What is the probability that neither of them is a carrier?
d. What is the probability that one of them is a carrier and the other is not?

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gladiator answered 3 hours ago
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