Question

In: Biology

The role of glucose-6-phosphate dehydrogenase against reactive oxygen species in cellular defense (give example, evidence)

The role of glucose-6-phosphate dehydrogenase against reactive oxygen species in cellular defense
(give example, evidence)

Solutions

Expert Solution

Ans. The role of glucose -6 - phosphate dehydrogrdehy play a key role in protection against reactive oxygen species (ROS) . Ros generated in oxidative metabolism inflict demage on all classes of macromolecules and can ultimately lead to cell death . ROS are implicated in a number of human disease . Reduced glutathione (GSH) ,a tripeptide with a free sulfhydryl group,is required to combat oxidative stress and maintain the normal reduced state in the cell.

Oxidased glutathione( GSSG) is reduced by NADPH generated by g6- pd ,in the pentose phosphate pathway . Cells with reduce level of glu-6- pd are specially sensitive to oxidative stress . This stress is most acute in red blood cell because , lacking mitochondria , they have no alternative means of reducing power

Eg.deficiency cause a drug - induced hemolytic anemia.

Deficiency Confers an evolutionary advantage in some circumstances ( protect against falciparum malaria . )


Related Solutions

What would happen to cellular glucose-6-phosphate if the pentose phosphate pathway is inhibited?
What would happen to cellular glucose-6-phosphate if the pentose phosphate pathway is inhibited?
The hydrolysis of glucose-6- phosphate to give glucose plus phosphate has a ∆G o = -...
The hydrolysis of glucose-6- phosphate to give glucose plus phosphate has a ∆G o = - 3.3 kcal/mol. In the liver glucose concentrations are extremely high during the fed state because of the proximity of the liver to the portal vein, and thus hydrolysis should be unfavorable. What is ∆G for this hydrolysis reaction at 0.5 M glucose, 0.01 M phosphate and 10 -6 M for glucose-6- phosphate? (Assume 2.303RT = 1360 cal/mol.) A. -3460 cal/mol B. -1730 cal/mol C....
1. The conversion of glucose 6-phosphate to fructose 6-phosphate is readily reversible. What cellular condictions would...
1. The conversion of glucose 6-phosphate to fructose 6-phosphate is readily reversible. What cellular condictions would bias the reaction in the direction of fructose 6-phosphate formation? 2. why is this isomerization critical in subsequent steps?
Suggest reasons why glucose 6-phosphate dehydrogenase deficiency may be manifested in red blood cells but not...
Suggest reasons why glucose 6-phosphate dehydrogenase deficiency may be manifested in red blood cells but not in adipocytes, which also require NADPH for their metabolism. Make sure to explain your reason.
Fatty Acid Degradation a) Cells with decreased glucose 6-phosphate dehydrogenase activity are more sensitive to oxidative...
Fatty Acid Degradation a) Cells with decreased glucose 6-phosphate dehydrogenase activity are more sensitive to oxidative stress because?   b) What cellular conditions typically enhance fatty acid degradation? c) What molecule transports fatty acids into the mitochondria? d)  Hydroxybutyrate and acetoacetate are both ketone bodies derived during the degradation of fatty acids. How are ketone bodies used by the body?
Which statement about glucose-6-phosphate dehydrogenase (G6PD) deficiency is FALSE? a. The enzyme deficient causes the decrease...
Which statement about glucose-6-phosphate dehydrogenase (G6PD) deficiency is FALSE? a. The enzyme deficient causes the decrease in NADPH production b. The deficient enzyme causes abnormal glob in production It is common inAfrica, Middle East, South East Asia and Mediterranean regions d. It is a male-dominant disease e. None of the above. All of the above statements are true for G6PD
The X-linked allele for glucose 6-phosphate dehydrogenase deficiency (Gd-) also confers resistance to malaria. You make...
The X-linked allele for glucose 6-phosphate dehydrogenase deficiency (Gd-) also confers resistance to malaria. You make a microscopic examination of the blood of a woman suffering from malaria. You observe that about one-half of the cells contain parasites, whereas one-half of the cells are unaffected. Explain this result.
(Q001) Glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency) is an inherited disorder where either the body has less...
(Q001) Glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency) is an inherited disorder where either the body has less of the G6PD enzyme than normal or the available G6PD is not functioning correctly. This deficiency affects red blood cell function and may result in anemia (the destruction of red blood cells) when people with the condition have infections, are taking certain medications, or eat certain foods. People with G6PD deficiency may have some protection from malaria because their abnormal red blood cells interfere...
Which statements about glucose-6-phosphate dehydrogenase are correct? Multiple answers: You can select more than one option...
Which statements about glucose-6-phosphate dehydrogenase are correct? Multiple answers: You can select more than one option A It catalyzes the committed step in the pentose phosphate pathway. B It is regulated by the availability of NAD+. C One of its products is 6-phosphogluconate. D It contains thiamine pyrophosphate as a cofactor. E It is important in the reduction of glutathione in erythrocytes.
ADVERTISEMENT
ADVERTISEMENT
ADVERTISEMENT