Question

Which statement about glucose-6-phosphate dehydrogenase (G6PD) deficiency is FALSE?

a. The enzyme deficient causes the decrease in NADPH production

b. The deficient enzyme causes abnormal glob in production

It is common inAfrica, Middle East, South East Asia and Mediterranean regions

d. It is a male-dominant disease

e. None of the above. All of the above statements are true for G6PD

Answer 1

E. All the statements are correct.

Glucose-6-phosphate dehydrogenase is responsible for the first step in the pentose phosphate pathway, a series of chemical reactions that convert glucose (a type of sugar found in most carbohydrates) to another sugar, ribose-5-phosphate. Ribose-5-phosphate is an important component of nucleotides, which are the building blocks of DNA and its chemical cousin RNA. This chemical reaction produces a molecule called NADPH, which plays a role in protecting cells from potentially harmful molecules called reactive oxygen species. These molecules are byproducts of normal cellular functions. Reactions involving NADPH produce compounds that prevent reactive oxygen species from building up to toxic levels within cells

The production of NADPH by glucose-6-phosphate dehydrogenase is essential in red blood cells, which are particularly susceptible to damage by reactive oxygen species because they lack other NADPH-producing enzymes.

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzyme deficiency in humans, affecting 400 million people worldwide. It has a high prevalence in persons of African, Asian, and Mediterranean descent. It is inherited as an X-linked recessive disorder. G6PD deficiency is polymorphic, with more than 300 variants.

It is x-linked recessive disorder.

Because men only have one X chromosome G6PD affects more men than women. If a man inherits G6PD deficiency on his one X chromosome which he gets from his mother he will be G6PD deficient.