1. The conversion of glucose 6-phosphate to fructose 6-phosphate is readily reversible. What cellular condictions would...

1. The conversion of glucose 6-phosphate to fructose 6-phosphate is readily reversible. What cellular condictions would bias the reaction in the direction of fructose 6-phosphate formation?

2. why is this isomerization critical in subsequent steps?

Expert Solution

Because of very small standard change in free energy (1.7kJ/mol), the conversion of glucose 6-phosphate to fructose 6-phosphate is made readily reversible. Therefore, The conditions that would bias the reaction towards the products (fructose 6-phosphate), would be a higher concentration of(glucose 6-phosphate) i.e., the reactants and low concentration fructose 6-phosphate i.e., the products. Also, due to the difference between cellular and standard conditions, the cellular enzyme kinetics is also dependent on the requirement of the cell. In this way, F-6-P formation will occur when there is low concentration of ATP demanding for more energy and formation of ATP

2. isomerization of glucose 6-phosphate to fructose 6-phosphate is critical due to the fact that Isomerization leading to formation of a keto sugar (Fructose 6 phosphate) from aldo (Glucose 6 phosphate) sugar is necessary for carbanion stabilization in the fourth reaction step.

gladiator answered 2 years ago

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