What would happen to cellular glucose-6-phosphate if the pentose phosphate pathway is inhibited?

Expert Solution

In the ansence of pentose phoshpate pathway glucose 6- phosphate undergo glycolysis to produce energy. In glycolysis the glucose 6- phosphate will converted into fructose 6- phosphate in the presence of enzyme phosphoglucomutase. Then by the presence of enzyme phosphofructokinase, by using one molecule of ATP the fructose 6-phosphate is converted into fructose 1,6- bisphosphate. Fructose 1,6- bisphosphate is split into dihydroxyacetone phosphate (DHAP) and glyceraldehyde 3-phosphate (GAP) by the presense of the enzyme aldose.The DHAP and GAP are isomers. The enzyme triose-phosphate isomerase rapidly converts DHAP into GAP. Then the DHAP molecules are converted into 1,3-bisphosphoglycerate in the presence of glyceraldehyde 3-phosphate dehydrogenase. In the next step phosphoglycerokinase converts 1,3-bisphosphoglycerate into 3-phosphoglycerate. In this step one ATP molecule is formed. Then phosphoglycerate mutase relocates phosphate group from third carbon to second carbon to yield 2-phosphoglycerate. The enzyme enolase removes a molecule of water from 2-phosphoglycerate to form phosphoenolpyruvate (PEP). In the last step phosphpopenol pyruvate is converted into pyruvate in the presence of pyruvate kinase. This step also yield one molecule of ATP.

gladiator answered 2 years ago

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