What would happen to cellular glucose-6-phosphate if the pentose phosphate pathway is inhibited?

Expert Solution

In the ansence of pentose phoshpate pathway glucose 6- phosphate undergo glycolysis to produce energy. In glycolysis the glucose 6- phosphate will converted into fructose 6- phosphate in the presence of enzyme phosphoglucomutase. Then by the presence of enzyme phosphofructokinase, by using one molecule of ATP the fructose 6-phosphate is converted into fructose 1,6- bisphosphate. Fructose 1,6- bisphosphate is split into dihydroxyacetone phosphate (DHAP) and glyceraldehyde 3-phosphate (GAP) by the presense of the enzyme aldose.The DHAP and GAP are isomers. The enzyme triose-phosphate isomerase rapidly converts DHAP into GAP. Then the DHAP molecules are converted into 1,3-bisphosphoglycerate in the presence of glyceraldehyde 3-phosphate dehydrogenase. In the next step phosphoglycerokinase converts 1,3-bisphosphoglycerate into 3-phosphoglycerate. In this step one ATP molecule is formed. Then phosphoglycerate mutase relocates phosphate group from third carbon to second carbon to yield 2-phosphoglycerate. The enzyme enolase removes a molecule of water from 2-phosphoglycerate to form phosphoenolpyruvate (PEP). In the last step phosphpopenol pyruvate is converted into pyruvate in the presence of pyruvate kinase. This step also yield one molecule of ATP.

gladiator answered 1 year ago

1. The conversion of glucose 6-phosphate to fructose 6-phosphate is readily reversible. What cellular condictions would...

1. The conversion of glucose 6-phosphate to fructose 6-phosphate is readily reversible. What cellular condictions would bias the reaction in the direction of fructose 6-phosphate formation? 2. why is this isomerization critical in subsequent steps?

Describe how the Pentose Phosphate pathway give organisms an advantage.

5. Look at the transaldolase mechanism in the Pentose Phosphate Pathway. What role does the Schiff...

5. Look at the transaldolase mechanism in the Pentose Phosphate Pathway. What role does the Schiff base play in this mechanism?

This question is about the pentose phosphate pathway and interconnected metabolic pathways (glycolysis, gluconeogenesis.) a) What...

This question is about the pentose phosphate pathway and interconnected metabolic pathways (glycolysis, gluconeogenesis.) a) What reactions would occur if the cell needed lots of NADPH and only NADPH? b) What reactions would occur if both NADPH and ATP were both needed? c) What reactions would occur if nucleotides were needed for DNA synthesis and that was the primary need?

What are the three phases of PPP and it’s outcomes? Topic is: Pentose phosphate pathway Thank...

What are the three phases of PPP and it’s outcomes? Topic is: Pentose phosphate pathway Thank you!

The pentose phosphate pathway ismost tightly integrated with which metabolic pathway in mammals? (a) glycolysis (b)...

The pentose phosphate pathway ismost tightly integrated with which metabolic pathway in mammals? (a) glycolysis (b) TCA cycle (c) tricarboxylate transport pathway (d) fatty acid oxidation (e) fatty acid elongation

please answer 1-6 :) 1. Choose the CORRECT enzyme–substrate pair from the pentose phosphate pathway. a....

please answer 1-6 :) 1. Choose the CORRECT enzyme–substrate pair from the pentose phosphate pathway. a. transaldolase – xylulose 5-phosphate b. glucose 6-phosphate dehydrogenase – 6-phosphoglucono-δ-lactone c. 6-phosphogluconate dehydrogenase – 6-phosphoglucono-δ-lactone d. transketolase – xylulose 5-phosphate e. lactonase – ribulose 5-phosphate 2. Choose the enzymes that catalyze reactions with concomitant formation of NADPH. a. glucose 6-phosphate dehydrogenase and lactonase b. transketolase and transaldolase c. phosphofructokinase and 6-phosphogluconate dehydrogenase d. glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase e. phosphopentose epimerase and glucose...

An organism that possesses all the enzymes of the EMP and Pentose Phosphate pathway has remarkable...

An organism that possesses all the enzymes of the EMP and Pentose Phosphate pathway has remarkable metabolic flexibility. Consider, for example, the need that organisms have for erythrose-4-phosphate. Devise a metabolic sequence that will accomplish net synthesis of erythrose-4-phosphate from glucose without the accumulation of any other intermediates. (10 points).

Of the following enzymes from the Pentose Phosphate Pathway, which one interconverts a single monosaccharide into...

Of the following enzymes from the Pentose Phosphate Pathway, which one interconverts a single monosaccharide into its constitutional isomer? A. Lactonase B. Transketolase C. Hexokinase D. Phosphopentose Epimerase

In the pentose phosphate pathway draw out all the structures, with names, enzymes and cofactors, encountered...

In the pentose phosphate pathway draw out all the structures, with names, enzymes and cofactors, encountered in the conversation of glucose-6-phosphate to ribose-5-phosphate

Question