Which statements about glucose-6-phosphate dehydrogenase are correct? Multiple answers: You can select more than one option...

Which statements about glucose-6-phosphate dehydrogenase are correct? Multiple answers: You can select more than one option

A It catalyzes the committed step in the pentose phosphate pathway.

B It is regulated by the availability of NAD+.

C One of its products is 6-phosphogluconate.

D It contains thiamine pyrophosphate as a cofactor.

E It is important in the reduction of glutathione in erythrocytes.

Solutions

Expert Solution

Ans. A It catalyzes the committed step in the pentose phosphate pathway.

C One of its products is 6-phosphogluconate.

E It is important in the reduction of glutathione in erythrocytes.

The enzyme glucose-6-phosphate dehydrogenase help in protection of red blood cell from damage and premature destruction. It is responsible for the first step of Pentose phosphate pathway, in converting glucose to other sugar i.e. ribose-5-phosphate and it catalyses the conversion of glucose 6-phosphate to 6-phosphogluconolactone and this then hydrolysed to form 6-phosphogluconate. The TPNH2(Reduced Triphosphopyridine nucleotide) is necessary for the reduction of glutathione in erythrocytes and TPNH2 is derived by the first step of pentose phosphate pathway which is catalysed by glucose-6-phosphate dehydrogenase.So glucose-6-phosphate dehydrogenase has an important role in reduction of glutathione in erythrocytes.

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gladiator answered 1 year ago

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