Suggest reasons why glucose 6-phosphate dehydrogenase deficiency may be manifested in red blood cells but not...

Suggest reasons why glucose 6-phosphate dehydrogenase deficiency may be manifested in red blood cells but not in adipocytes, which also require NADPH for their metabolism. Make sure to explain your reason.

Solutions

Expert Solution

glucose 6-phosphate dehydrogenase produces NADPH that is used by the different enzymes like glutathione peroxidase to neutralize the reactive oxygen species that can cause excessive damage to the cells if left active. The production of reactive oxygen species increases in the presence of oxygen. This is the RBC that is responsible for oxygen transport and do not operate ETC for the reduction of excess oxygen, hence the environment in RBC is always oxidative and so much of reactive oxygen species are produced which are neutralized by the enzyme by using NADPH produced by the glucose 6-phosphate dehydrogenase under normal circumstances. On the other hand in adipocytes, the oxygen level are very low and whatever the oxygen enters the adipocyte is reduced into the water by ETC. This prevents the generation of reactive oxygen species. Now if glucose 6-phosphate dehydrogenase is not present in RBC due to mutation in the genes, RBCs would not be able to neutralize the reactive oxygen species due to lack of NADPH. this cause excessive damage to the cell leading hemolysis and death of RBC. Adipocytes remain unaffected due to the small requirement for oxygen that is used in ETC and this reduces the reactive oxygen species. Hence are not prone to damage. So this is why RBC's manifests the glucose 6-phosphate dehydrogenase deficiency but not adipocytes.

gladiator answered 1 year ago

Next > < Previous

Related Solutions

(Q001) Glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency) is an inherited disorder where either the body has less...

(Q001) Glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency) is an inherited disorder where either the body has less of the G6PD enzyme than normal or the available G6PD is not functioning correctly. This deficiency affects red blood cell function and may result in anemia (the destruction of red blood cells) when people with the condition have infections, are taking certain medications, or eat certain foods. People with G6PD deficiency may have some protection from malaria because their abnormal red blood cells interfere...

Which statement about glucose-6-phosphate dehydrogenase (G6PD) deficiency is FALSE? a. The enzyme deficient causes the decrease...

Which statement about glucose-6-phosphate dehydrogenase (G6PD) deficiency is FALSE? a. The enzyme deficient causes the decrease in NADPH production b. The deficient enzyme causes abnormal glob in production It is common inAfrica, Middle East, South East Asia and Mediterranean regions d. It is a male-dominant disease e. None of the above. All of the above statements are true for G6PD

Fatty Acid Degradation a) Cells with decreased glucose 6-phosphate dehydrogenase activity are more sensitive to oxidative...

Fatty Acid Degradation a) Cells with decreased glucose 6-phosphate dehydrogenase activity are more sensitive to oxidative stress because? b) What cellular conditions typically enhance fatty acid degradation? c) What molecule transports fatty acids into the mitochondria? d) Hydroxybutyrate and acetoacetate are both ketone bodies derived during the degradation of fatty acids. How are ketone bodies used by the body?

The X-linked allele for glucose 6-phosphate dehydrogenase deficiency (Gd-) also confers resistance to malaria. You make...

The X-linked allele for glucose 6-phosphate dehydrogenase deficiency (Gd-) also confers resistance to malaria. You make a microscopic examination of the blood of a woman suffering from malaria. You observe that about one-half of the cells contain parasites, whereas one-half of the cells are unaffected. Explain this result.

draw the mechanism for aldolase with glucose-6-phosphate that indicates why glucose-6-phosphate is not an appropriate substrate...

draw the mechanism for aldolase with glucose-6-phosphate that indicates why glucose-6-phosphate is not an appropriate substrate in terms of efficienty having a convergent pathway

During the first stage of iron deficiency, A. red blood cells are small and low in...

During the first stage of iron deficiency, A. red blood cells are small and low in number B. body stores of iron are depleted C. circulating iron in the blood is depleted D. physical symptoms of iron deficiency are apparent

84.The formation of glucose 6-phosphate renders the entry of glucose into most cells almost irreversible (i.e....

84.The formation of glucose 6-phosphate renders the entry of glucose into most cells almost irreversible (i.e. staying intracellular).True/False? 83.Glucagon targets primarily on liver to increase glycogen degradation.True/False? 82.The increase of glycogenolysis in muscle produced by epinephrine may be attributed to the conversion of phosphorylase b to phosphorylase a.True/False? 81.Measurement of blood ammonia level is a sensitive test of kidney function.True/False? 80.During starvation when gluconeogenesis increases to maintain the levels of blood glucose, the metabolism of glutamate to glucose-6-phosphate is enhanced.True/False?...

The role of glucose-6-phosphate dehydrogenase against reactive oxygen species in cellular defense (give example, evidence)

Unlike liver cells, muscle cells do not secrete glucose into the blood. What about glucose-6-P prevents...

Unlike liver cells, muscle cells do not secrete glucose into the blood. What about glucose-6-P prevents its secretion and how do liver cells overcome this problem? McArdle’s disease (also called glycogen storage disease V) is a genetic disorder in which muscle cannot make functional phosphorylase. Speculate as to why McArdle’s patients show muscle fatigue (tiredness) with even moderate exercise. McArdle’s disease is inherited as a recessive trait. Consider the activity of the phosphorylase enzyme and suggest an explanation for the...

The cell membranes of mammalian red blood cells are permeable to urea. If red blood cells...

The cell membranes of mammalian red blood cells are permeable to urea. If red blood cells are dropped into a solution of urea that is identical in osmotic pressure (isosmotic) to the cytoplasm of the cells, although the cells do not swell and burst as quickly as when they are dropped simply into pure water, they eventually swell and burst. Explain. Also discuss how you would design a solution into which red cells could be placed without ever swelling. (Hint:...

Subjects