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2. (6 pts) Speculate on the effects of each of the following mutations on the translation...

2. (6 pts) Speculate on the effects of each of the following mutations on the translation of the following mRNA. Specifically indicate whether any product would be made, and if so, if it would be altered in any way.  (GpppG is the 5’ cap)

5’GpppGUAACAUGGUCGGACCAUGAC(A)2003’

  1. Mutation that removes the editing pocket from isoleucine-tRNA synthetase.
  1. Mutation that prevents GTP hydrolysis of eEF1-a.
  1. Mutation that prevents binding of GTP by eEF2.

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