Question

Using diagrams, describe the differences between a chimeric and humanised human-mouse monoclonal antibody.

Answer 1

Chimeric monoclonal antibody	Humanised monoclonal antibody
Chimeric antibody refers to an antibody derived from both human and mouse DNA to which a chimeric region is also attached	Humanized antibody refers to an antibody made up of a combination of human antibody and a small part of a mouse or rat antibody
Chimeric Antibody has a large portion of a chimeric region	Humanized antibody does not have a chimeric region
Around 66% of human DNA is involved in the production of a chimeric antibody	Around 90% of human DNA is involved in the production of humanized DNA
Chimeric antibody helps to track down and illuminize tumor regions	Humanized antibodies are used to immunize humans
Chimeric antibodies are abciximab, rituximab, infliximab, and cetuximab	Humanized antibodies include palivizumab, trastuzumab, bevacizumab, and natalizumab

Monoclonal Antibodies (brown: human, blue: non-human)
top row: mouse, chimeric bottom row: humanized, chimeric/humanized, human