Question

1.Discuss the mechanisms that control the regulation of gene expression, after mRNA is transcribed.

•Cis- and Trans-acting elements

can u tell me plzz in brief

Answer 1

1) There are different mechanisms for controlling gene expression at translation level which differ in both prokaryotes and eukaryotes.

Prokaryotes control of gene expression:

i) Translational repressor proteins bind to mRNA and prevent translation.

ii)Antisense mRNA binding to mRNA

iii)Binding of metabolite to a riboswitch in mRNA

Eukaryotes control of gene expression:

i) Phosphorylation of translational intiation factors

ii) Binding of protein to 5' end of mRNA

iii) Antisense RNA binding to mRNA

iv) stability of mRNA can be influenced by RNA binding proteins.

Cis active elements - These elements control gene expression at transcription level. These elements gene are non coding DNA sequences which can regulate transcription of neighboring genes.

Trans active elements- These are also act as controller at transcription level. Unlike cis active element, these elements can control expression of gene distant from gene they have been transcribed. These elements are found to be bind on cis active elements.

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