Question

How do the following systems contribute to coagulation?

-Complement

-Fibrinolysis

-Kinin

Answer 1

Answere : Blood coagulation is a series of coordinated and calcium-dependent proenzyme-to-serine protease conversion likely to be lacalised on the surface of activated cells in vivo. It culminates in the formation of thrombin, the enzyme responsible for conversion of soluble fibrinogen to insoluble fibrin clot.

The kinin system is an endogenous system in an endogenous metabolic cascade, triggering of which result in the release of vasoactive kinase. Kinin peptides are implicated in many physiological and pathological processes including the regulation of blood pressure and sodium homeostasis, inflammatoryv processes, and the cardioprotective effectsof preconditioning.

Complement is a system of plasma proteins that is activated by the presence of pathogen. There are three pathways of complement activation: the classical pathway, lectin pathway and the alternative pathway. All of these pathways generate a crucial enzymatic activity that intern, generate effector molecule of complement. The three main consequence of complement activation are the opsonization of pathogen, the recruitment of inflammatory and immunocompetent cells and direct killing of pathogens.

Fibrnolysis is the mechanism of clot removal, and involves a cascade of interacting zymogen and enzymes that act in concert with clot formation to maintain blood flow.