Question

What is a question about morphogenesis of the primitive gut that you would like to further explore that hasn't been explored thus far and what type of experiment (explain in detail) could you come up with in order to test that new theory?

Answer 1

Morphogenesis of the digestive tract is a complex process that involves molecular and mechanical interactions between all germ layers. How genetic determinants influence mechanical forces is an area of ongoing investigation, but presents its own challenges. Myogenic contractions are initiated by the smooth muscle in the intestine is still to be determined, but the contraction of the cell is calcium dependent and thus modulators of calcium signaling are likely factors. Spontaneous calcium waves of enteric neural crest cells, and furthermore how each of these influence differentiation and morphogenesis of the developing digestive tract.

On introduction of spontaneous calcium wave, the gene expression study i through Microarray in enteric neural crest could lead to finding of how the calcium influence the myogenic contraction in digestive tract. the potential candidate gene responsible for this morphogenesis can be evaluated using gene deletion gen mutation and gene Overexpression model.