Question

what is the organ system involves the Gamma ( GT) liver function test

Answer 1

γGT (or) Gamma-Glutamyl Transpeptidase (GGT) (or) Gamma-Glutamyl Transferase.

Clinically GGT is predominantly used as a diagnostic marker for liver disease. It is an especially useful marker of obstructive liver diseases such as biliary obstruction, cholangitis and cholecystitis as compared to ALP, ALT or AST. Latent elevations in GGT are typically seen in patients with chronic viral hepatitis infections often taking 12 months or more to present. Serum GGT has also been found to be useful in assessing and following liver damage due to alcoholism and is a known risk predictor for the development of hepatoma and other cancers. It has also been used to predict treatment response in patients with hepatitis C, with a high pre-treatment serum level of GGT usually predicting a poor response to treatment. It has also been reported that GGT is an independent risk factor for developing type 2 diabetes. Thus GGT is a remarkably useful and versatile marker.

GGT is present in the cell membranes of many tissues, including the, liver, kidneys, bile duct, pancreas, gallbladder, spleen, heart, brain, and seminal vesicles. It is involved in the transfer of amino acids across the cellular membrane and leukotriene metabolism. It is also involved in glutathione metabolism by transferring the glutamyl moiety to a variety of acceptor molecules including water, certain L-amino acids, and peptides, leaving the cysteine product to preserve intracellular homeostasis of oxidative stress. This general reaction is shown in the above diagram.

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