What would be the effect of removing the ligand binding domain of Estrogen receptor and replacing...

What would be the effect of removing the ligand binding domain of Estrogen receptor and replacing it with the ligand binding domain of retinoic acid receptor? (5 Points)

What would be the effect of mutating the DNA binding domain of the glucocorticoid receptor? (5 Points)

Expert Solution

Ans :- Estrogens pass directly into cells throughout the body, so the cell can use receptors, that are in the nucleus, right at the site of action on the DNA.When estrogen enters the nucleus, it binds to the estrogen receptor, causing it to pair up and form a dimer.

Glucocorticoid receptor (GR, or GCR) also known as NR3C1(nuclear receptor subfamily 3, group C, member 1) is the receptor to which cortisol and other glucocorticoids bind.

The GR is expressed in almost every cell in the body and regulates genes controlling the development, metabolism, and immune response.

The glucocorticoid receptor (GR) is a ubiquitously expressed DNA-binding transcription factor (TF) that directly regulates thousands of genes associated with stress response, inflammation, and apoptosis, if mutation occur in them it will lead to responses of body in conditions in stress and inflammation is deprived.

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gladiator answered 2 years ago

Diagram an adrenergic receptor. Label the ligand-binding domain. Label the transmembrane domain. Label the intracellular domain....

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Why do hormones/steroids have a ligand-binding domain and a DNA-binding domain? Does it need its receptor...

Why do hormones/steroids have a ligand-binding domain and a DNA-binding domain? Does it need its receptor to attach to DNA?

What does binding of its ligand do to a receptor kinase?

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1. All signaling begins with the binding a soluble ligand to a receptor on the exterior...

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In studying receptor-ligand interactions, the researcher wanted to narrow down the exact region of binding between...

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You think you have a receptor with three identical and independent ligand binding sites that came...

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What do you envision for the structure of estrogen receptor receptor-bound estradiol?

Cro and cI proteins both have helix-turn-helix DNA binding domains. What effect would replacing cro’s DNA...

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