Briefly describe the 3 signals involved in the activation and differentiation of a naive CD4+ T...

Briefly describe the 3 signals involved in the activation and differentiation of a naive CD4+ T cell into an effector Th2 (T helper) cell.

Expert Solution

The naive CD4+ T cell gets activated due to the secretion of IL-4 that activates this cell to become the Th2 T cell in the immune system. The activation response of the naive CD4+ T cell involves the interaction of the receptors with the receptor molecules like the major histocompatibility factors present on the surface of the antigen presenting cell. The 3 cell signaling mechanisms are given below as follows:

The interaction of T-cell receptor with the MHC-II complex and antigen processed peptide present on the surface of the antigen presenting cell.
The interaction of the CD 28 receptor( cluster of differentiation) present on the surface of the CD4 cell with the CD80/CD86(B7 receptor) receptor present on the surface on the antigen presenting cell.
The interaction of the CD27/CX40 receptor present on the CD4 cell with the CD70/CX40L ligand present on the surface of the antigen presenting cell. These pathways initiate and activate the conversion of the naive CD4 + Tcell into the Th2 T cell in the immune system.

The interaction of these receptors along with the processed antigen in the major histocompatibility complex causes the activation of the cell signaling mechanism necessary for the activation response in the CD4+ T cell.

gladiator answered 1 year ago

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