What are the 3 signals of T-cell activation and how do they each work?

Solutions

Expert Solution

Answer =

3 signals of T-cell activation are as follows:

Signal 1: The T cells are genetared in Thymus they are activated we then recognises an antigen.they recognises their antigen on the surface of antigen binding cells.

on the surface of antigen binding cells (APCs) there is presence of major histocompability complex molecules (MHCs)

Both types of T cells that is CD4+ and CD8+ are bound to the MHC molecule present on antigen binding cells.

2.Signal Two 2 = Both types of T cell that is

helper T cell - the signal is provided by CD28.This CD28 binds to the B7 present on APC. when CD28 binds to the B7 the process of T cell proliferation initiated.

Cytotoxic T cell - require costimulatory molecules such as CD70 and CD 137.

3.Signal three =

for TH 1 cell type - signal is IL-2

TH2 cell type - IL-4

gladiator answered 1 year ago

Next > < Previous

Related Solutions

Briefly describe the 3 signals involved in the activation and differentiation of a naive CD4+ T...

Briefly describe the 3 signals involved in the activation and differentiation of a naive CD4+ T cell into an effector Th2 (T helper) cell.

Explain the 3 steps of T cell final maturation/activation. Describe what happens during each step. Then,...

Explain the 3 steps of T cell final maturation/activation. Describe what happens during each step. Then, describe what happens if negative stimulation occurs during this process and explain WHY the body would use negative (instead of positive) stimulation.

Which of the following processes: T cell development, T cell activation, B cell development, B cell...

Which of the following processes: T cell development, T cell activation, B cell development, B cell activation would be disrupted by a deficiency in the indicated protein. Your answer should include all processes that would be disrupted. If none of these processes is disrupted, state NONE. Part 2: Justify your answers (a-d) by describing the cell type(s) that express the molecule and the function of the molecule in the processes you indicated would be disrupted. a. CD3 zeta chain b. TLR4...

How do B cell activation and differentiation take place?

Like T cells, B cells require multiple signals for activation. Antigen binding to the B cell antigen __________provides one signal

Like T cells, B cells require multiple signals for activation. Antigen binding to the B cell antigen __________provides one signal, while antigen-specific effector ________ provide the other signals. The requirement for multiple signals to activate either a T cell or a B cell helps to prevent _______ and dangerous activation of _________ , including __________ _________. Most of the proteins involved in cell–cell recognition and antigen recognition in the immune system, including _________ , TCRs, and _______ proteins, as well as various co-receptors,...

What are four signals that regulate cell division? Briefly explain how they are each involved in...

What are four signals that regulate cell division? Briefly explain how they are each involved in this control in preventing tumors.

What are some examples of cell survival signals? What are some examples of cell death signals?...

What are some examples of cell survival signals? What are some examples of cell death signals? Stem cells Cloning: read therapeutic (SCNT) vs. reproductive cloning iPs cells

We spent a lot of time comparing B cell and T cell surface molecules and activation...

We spent a lot of time comparing B cell and T cell surface molecules and activation – how they’re similar and different. For each of the following, compare similarities and differences. Make sketches where indicated. Feel free to use additional sketches if they help you learn the material. A. Compare the TH-Macrophage interaction (which activates TH cells) with the TH-B cell interaction (which activates B cells). Make a sketch of each interaction that shows the important cell surface proteins involved....

do enzymes work by increasing or decreasing activation energy??

The cell cycle control system responds to external and internal signals. What are four signals that...

The cell cycle control system responds to external and internal signals. What are four signals that regulate cell division? Briefly explain how they are each involved in this control in prevent tumors. Briefly explain what the differences are between a benign and a malignant tumor and how cancer cells are different than normals cells (what are they) and include how tumor suppressors proto-oncogenes work. What should males and females be checking every month.

Subjects