the ability of hemoglobin (Hb) to carry oxygen throughout the body as oxyhemoglobin (HbO2) is dependent...

the ability of hemoglobin (Hb) to carry oxygen throughout the body as oxyhemoglobin (HbO2) is dependent on the pH of the blood, What effect would acidosis have on the ability of a patient to transport oxygen? HbH+ and O2 -> HbO2 and H+

Expert Solution

queen_honey_blossom answered 3 years ago

In the body, hemoglobin (Hb) is the substance responsible for transporting oxygen (O2) to tissues. Hemoglobin...

In the body, hemoglobin (Hb) is the substance responsible for transporting oxygen (O2) to tissues. Hemoglobin binds oxygen to produce oxyhemoglobin (HbO2): Hb + O2 ? HbO2 Carbon monoxide (CO) can also bind to hemoglobin to produce carboxyhemoglobin (HbCO): Hb + CO ? HbCO The equilibrium constant for Reaction 2 (KCO) is about 210 times larger than the equilibrium constant for Reaction 1 (KO2). Thus, carbon monoxide binds to hemoglobin much more efficiently than oxygen. KCO/KO2 = 210 a. Write...

describe the structure of hemoglobin. how many oxygen molecules does each hemoglobin carry? where are senescent...

describe the structure of hemoglobin. how many oxygen molecules does each hemoglobin carry? where are senescent blood cells and hemoglobin broken down? what are the breakdown products of hemoglobin? how can the excessive breakdown of RBC's cause jaundice?

Describe in 3-4 sentences how the hemoglobin (Hb) in red blood cells delivers more oxygen to...

Describe in 3-4 sentences how the hemoglobin (Hb) in red blood cells delivers more oxygen to active cells, than cells at rest. Include, differences in partial pressure, pH, and [carbon dioxide]. (There might be a very small effect of temperature, but you can leave it out because it is a minor contributor in humans.)

Adult hemoglobin (iron-containing protein) can carry up to four oxygen molecules per hemoglobin molecule, with the...

Adult hemoglobin (iron-containing protein) can carry up to four oxygen molecules per hemoglobin molecule, with the addition of oxygen proceeding in a step-wise fashion. For the third step, the value of the equilibrium constant is Keq=5.86 x 10^-4 although the reaction has a (delta Hº) value of -2.9 kj/mol (Remember that the system is not at room temperature). Heme-Fe^2+ -(O2)2 + O2 <----> Heme-Fe^2+ -(O2)3 Keq=5.86 x 10^-4 (a) calculate delta Gº for this process. (b)From the information provided, calculate...

You want to study the oxygen binding ability of hemoglobin at pH 7.21 and pH 7.60....

You want to study the oxygen binding ability of hemoglobin at pH 7.21 and pH 7.60. You decide to use a phosphate buffer. a) How would you make up 500 ml of 50 mM phosphate buffer, pH 7.21, starting with 1.00 M H3PO4 and either 10.0 M HCl or 10.0 M NaOH? 25 ml 1M H3PO4, 3.75 ml 10.0 M NaOH, and 471.25 ml H2O. b) How would you make up 500 ml of 50 mM phosphate buffer, pH 7.60,...

According to the Oxygen-Hemoglobin Saturation Curve (= Oxygen-Hemoglobin Dissociation Curve):

Neither myoglobin or sickle-cell hemoglobin will work for oxygen transport in the body. Using your extensive...

Neither myoglobin or sickle-cell hemoglobin will work for oxygen transport in the body. Using your extensive knowledge of these proteins, explain why this is true. Additionally, explain the effect of decreasing pH and 2,3-BPG on the action of a normal molecule of hemoglobin.

1. List the sources of errors in hemoglobinometry. 2. Differentiate oxyhemoglobin, deoxygenated hemoglobin, carboxyhemoglobin and methemoglobin....

1. List the sources of errors in hemoglobinometry. 2. Differentiate oxyhemoglobin, deoxygenated hemoglobin, carboxyhemoglobin and methemoglobin. 3. Give the clinical importance of hemoglobin determination.

Topic 9: Oxygen-hemoglobin dissociation curve Define what the oxygen hemoglobin dissociation curve is and describe why...

Topic 9: Oxygen-hemoglobin dissociation curve Define what the oxygen hemoglobin dissociation curve is and describe why it is physiologically important. explain the significance of the sigmoidal shape, including the physiological significance of the plateau and step portions, and the relationship between oxygen loading/unloading with changes to po2 Give an example of a situation/condition that would result in a right shift of the oxygen hemoglobin dissociation curve. explain what causes the shift and relate it to oxygen binding affinity, loading-unloading of...

Which of the following will decrease the affinity of oxygen for hemoglobin at low oxygen partial...

Which of the following will decrease the affinity of oxygen for hemoglobin at low oxygen partial pressures and shift the oxyhemoglobin saturation curve to the right, resulting in increased oxygen unloading for active tissues? Select one: a. high CO2 b. low H+ c. low temperature d. high hemoglobin levels e. low CO2

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