Neither myoglobin or sickle-cell hemoglobin will work for oxygen transport in the body. Using your extensive...

Neither myoglobin or sickle-cell hemoglobin will work for oxygen transport in the body. Using your extensive knowledge of these proteins, explain why this is true. Additionally, explain the effect of decreasing pH and 2,3-BPG on the action of a normal molecule of hemoglobin.

Expert Solution

gladiator answered 2 years ago

people with sickle cell anemia have deformed red blood cells that cant properly transport oxygen to...

people with sickle cell anemia have deformed red blood cells that cant properly transport oxygen to cells. compared to a healthy human, sickle cell patients would be mostly defective in? a) osmosis b)ATP production c) glycolysis d) fermentation

Hemoglobin and Myoglobin, HOW is oxygen binding regulated? what other mechanisms control oxygen binding in oxygenated...

Hemoglobin and Myoglobin, HOW is oxygen binding regulated? what other mechanisms control oxygen binding in oxygenated vs deoxygenated tissues ( lung v. exercising muscles)?

describe the actuve location (S) of hemoglobin and myoglobin. How does the former function to transport...

describe the actuve location (S) of hemoglobin and myoglobin. How does the former function to transport 02 from the lungs to the cells where it is used?

Explain, how following conditions influence affinity of hemoglobin and myoglobin to oxygen: a) falling of pH...

Explain, how following conditions influence affinity of hemoglobin and myoglobin to oxygen: a) falling of pH in blood plasma from pH=7.4 to pH=7.2. b) falling of partial pressure of CO2 from 6 kPa to 2 kPa c) Increase in BPG level from 5 mM to 8 mM.

Both myoglobin and hemoglobin exhibit cooperative binding to oxygen true or false Tropocollagen is a double...

Both myoglobin and hemoglobin exhibit cooperative binding to oxygen true or false Tropocollagen is a double helix of two left handed polypeptide chains true or false F actin is a polymer of G actin monomers and exhibits symmetry true or false Proteins have an asymmetrical tertiary structure, while multisubunit proteins can exhibit several types of symmetry true or false When referring to the amino acid sequences of proteins, sequence homology is the same as sequence similarity. true or false

Building on Dr. Allisons work on Sickle Cell anemia Dr. Pauling tested hemoglobin from diseased individuals,...

Building on Dr. Allisons work on Sickle Cell anemia Dr. Pauling tested hemoglobin from diseased individuals, normal individuals and heterozygotes using ____________ technique.

In the body, hemoglobin (Hb) is the substance responsible for transporting oxygen (O2) to tissues. Hemoglobin...

In the body, hemoglobin (Hb) is the substance responsible for transporting oxygen (O2) to tissues. Hemoglobin binds oxygen to produce oxyhemoglobin (HbO2): Hb + O2 ? HbO2 Carbon monoxide (CO) can also bind to hemoglobin to produce carboxyhemoglobin (HbCO): Hb + CO ? HbCO The equilibrium constant for Reaction 2 (KCO) is about 210 times larger than the equilibrium constant for Reaction 1 (KO2). Thus, carbon monoxide binds to hemoglobin much more efficiently than oxygen. KCO/KO2 = 210 a. Write...

Sickle cell anemia is a recessive disorder caused by a mutation in the hemoglobin A gene....

Sickle cell anemia is a recessive disorder caused by a mutation in the hemoglobin A gene. Persons with the disease have a variety of serious health issues related to fragile and sickling red blood cells including premature death, and infants sometimes die from complications. In regions of central Africa where malaria is endemic, the relative fitnesses for individuals that are homozygous for the wild type hemoglobin allele (HbA), heterozygous (HbAHbS), and homozygous for the sickle cell allele (HbS) are 0.8,...

abnormal hemoglobin that causes sickle cell is an example of a mutation that is: a)both adaptive...

abnormal hemoglobin that causes sickle cell is an example of a mutation that is: a)both adaptive in areas without malaria and maladaptive in areas with malaria b)adaptive in areas with malaria c)maladaptive in areas with malaria d)adaptive in areas without malaria

Gas Transport in the Blood. Efficient oxygen exchange requires the reversible binding of oxygen to hemoglobin....

Gas Transport in the Blood. Efficient oxygen exchange requires the reversible binding of oxygen to hemoglobin. Describe the relationship between the partial pressure of oxygen in the blood and the oxygen saturation of hemoglobin. Include a labeled figure that clearly shows this relationship. Then, explain in detail the significance of the relationship by discussing what is seen in “average” body tissues and tissues that are metabolically active (name them). Then, explain in detail the significance of the relationship with respect...

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