describe the process of antigen presentation of COVID-19 to
CD8+T cells. Include how the virus enters the cells, is processed
in the cells, and activates CD8 T cells.
11. Describe the process of antigen recognition/presentation for
T-cell subsets. Include the following in your response:
a. Role of activation & antigen presenting cells
b. MHC molecules involved
c. Restricted recognition
d. Co-receptors
e. Signaling
f. Cytokines stimulated or responded to
g. Cells stimulated
Below draw AND LABEL the cell in a timeline as it is
encountered by a CD8 T-cell in each of the three steps
1. the virally infected cell. Show MHC I displaying endogenous
and autoantigens
2. recognition of your cell by a Cytotoxic T-lymphocyte (include
MHC I, TCR, and CD8 proteins)
3. the outcome of this recognition (include perforins and
granzymes)
Based on what you have learned about antigen presentation, T cells,
and viral infections, describe the process of antigen presentation
of COVID-19 to CD8+T cells. Include how the virus enters the cells,
is processed in the cells, and activates CD8 T cells.
Virus is a typical endogenous antigen. First explain
its pathway of antigen presentation, second how many mechanisms do
we have in immune response against virus infection?
Antigen processing would involve which of the following for antigen
-presenting cells?
The immune cells take peptides 8 - 10 amino acids long
directly from which organelle in the cytosol?
How does the immune system recognize that a cell is infected
with a virus?
Describe the mechanism of action of the drug ZAVESCA
Briefly describe the normal cell biology, the pathogenic state
and how the drug alters the pathogenic state.
Come up with an experimental plan by which you can prove where
in the cell the drug acts; what cellular functions it modulates,
and the mechanism by which it works.