If a histidine sidechain in a binding site is protonated in the free protein, but deprotonated...

If a histidine sidechain in a binding site is protonated in the free protein, but deprotonated in the ligand-bound state, how would pH affect the interaction?

A.) No effect

B.) Lower Kd at lower pH

C.) Higher Kd at lower pH

D.) Only ΔH would change with pH

Solutions

Expert Solution

queen_honey_blossom answered 8 months ago

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