Question

1a. The term “transcription factor binding site” (aka TF binding site) refers to __

1b. Transcription factor binding sites are often found where within genomic DNA?

1c. Transcription factor binding sites could be referred to as cis-acting elements because __

1d. Transcription factors (both activators and repressors) could also be referred to as trans-acting factors because __

 Terms

 Lac operon

 Operator

 Repressor protein

 CAP (catabolite activator protein)

 Trans acting factors vs. Cis acting elements

 Transcription factor

 Transcriptional activator vs. repressor

 DNA-binding domain

 Transcription factor binding site

 Activation vs. Repression domains

 Chromatin

 Nucleosome

 10nm- vs. 30nm-fibers

 Euchromatin vs. heterochromatin

 Histones vs. core histones vs. H1 linker histone vs. nucleosome core particle

 Histone-fold domain vs. amino terminal tail domain

 Histone Acetylation

 Histone acetyltransferase (HAT)

 Histone deacetylase (HDAC)

 Chromatin decondensation vs. chromatin condensation

 Transcriptional coactivators & corepressors

Answer 1

Transcription factor binding site refers to DNA binding sites and associated to specialized proteins called trans factor which is refered as it's cistrome ( cis acting targets of a trans acting factors on a genome wide scale) .

Transcription factor binding site are often found where within genomic DNA. Transcription factors are regulatory regions of DNA . They are well known as promotors or enhancer, where they control the transcription or expression of target genes.

Transcription factors binding sites could be refered to cis acting elements because it is on the same chromosome just next to the gene.

Transcription factors could also be referred to as trans acting factors because these are usually protein binding factors binding to the cis acting sequence to control gene expression.