How is Histidine used to modulate protein activity?

Expert Solution

queen_honey_blossom answered 2 years ago

If a histidine sidechain in a binding site is protonated in the free protein, but deprotonated...

If a histidine sidechain in a binding site is protonated in the free protein, but deprotonated in the ligand-bound state, how would pH affect the interaction? A.) No effect B.) Lower Kd at lower pH C.) Higher Kd at lower pH D.) Only ΔH would change with pH

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Question

How is Histidine used to modulate protein activity?

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Related Solutions

If a histidine sidechain in a binding site is protonated in the free protein, but deprotonated...

how do non protein coding sequences affect gene expression and protein activity

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