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In: Chemistry

For the peptide below Thr, Ser, Tyr, Met, Asp, Phe, His, Lys, Trp, Gly, Pro, Arg,...

For the peptide below

Thr, Ser, Tyr, Met, Asp, Phe, His, Lys, Trp, Gly, Pro, Arg, Ile, Glu

Calculate overall charge for pH=5 and pH=11 Calculate overall pI

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The amino acid sequence of human adrenocorticotropin, a polypeptide hormone, is: Ser-Tyr-Ser-Met-Glu-His-Glu-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-Asp-Ala-Gly-Glu-Asp-Gln-Ser-Ala-Glu-Ala-Glu-Pro-Leu-Glu-Phe a)What is the approximate net charge of this molecule at pH 3? ph 7? ph 9? Assume that the pKs of the terminal -NH3+ and -COOH groups are 7.8 and 3.6, respectively.
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