Question

In: Anatomy and Physiology

​​​​​​​this is a pharmacology question In not more than a paragraph each, explain the role of...

​​​​​​​this is a pharmacology question

  1. In not more than a paragraph each, explain the role of the following classes of drugs in heart failure with 2 examples each.
    1. Diuretics
    2. Beta blockers
    3. ACE Inhibitors
    4. Cardiac glycosides
    5. Vasodilators

Solutions

Expert Solution

a. ANSWER: Diuretics commonly used in heart failure are furosemide, bumetanide. The mechanism of action is by excretion of excess of sodium and water from the body that makes heart to pump easily. It also makes breathing easier.

b. ANSWER: Beta blockers are best suited for the treatment of diastolic heart failure. This allows the left ventricle to fill completely and increase the volume of blood that is ejected out of the heart with each heartbeat. The commonly used beta blocker in heart failure are carvedilol, bisoprolol.

c. ANSWER: ACE inhibitors like captopril, enalopril are used in the treatment of heart failure. They help by reducing the blood pressure and relaxes the blood vessel.

d. ANSWER: Cardiac glycosides like digoxin will increase the release of calcium from the sarcoplasmic reticulum of the heart muscle that would increase the cardiac output with minimal heart rate and without any significant changes in the blood pressure.

e. ANSWER: Vasodilators would help in the treatment of heart failure by dialting the blood vessel that would reduce the blood pressure. The most common Vasodilators used are nitroglycerin, nitroprusside and hydralazine.

Sydney Mullin answered 1 year ago
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