Question

What would be a good mechanism presentation over "Why is it important to be in a caloric deficit when attempting to lose weight? "

We must break it down into the cellular level of things and I have no clue where to start.

Answer 1

What would be a good mechanism presentation over "Why is it important to be in a caloric deficit when attempting to lose weight?

Carolie deficit arises when more calories are burned than the intake. It is important to maintain calorie deficit when trying to lose weight because that there is less energy intake, metabolism will shift to stored energy to compensate the demand. Factors that contribute to create a calorie deficit are:

TEF - Thermal effect of food: calories spent for digestion.

NEAT -  Non-Exercise Activity Thermogenesis- calories burnt from activity that is not exercise.

BMR - Basal metabolic rate

Calorie restriction is the reduction in calorie intake without malnutrition. The metabolic shift occurs with fatty acids and fatty acid-derived ketones from utilization of glucose from glycogenolysis. Recent studies revelas that ketones also acts as a preferred fuel for brain along with glucose which is the most preferrred fuel. In context to weight loss, it causes mobilization of fat in the form of free fatty acids and ketones than lipid synthesis and fat storage. Lipids of adipose tissues are convertedand released into blood stream as FFAs to reach the target organ, liver. The hepatocytes of liver carry out β-oxidation to produce the ketones β-OHB and acetoacetate that further stimulate mitochondrial biogenesis.