Draw the Sn1 intermediate and Sn2 transitions state for both
ethyl-2-chloroacetate and benzyl bromide (α-bromotoluene). Use
these structures to explain the differences in reactivity between
these two compounds.
Write equations for the reactions investigated. Label Sn1 or
Sn2.
1)Butyl bromide in 15%NaI-acetone
2)Butyl bromide in 1%ethanolic silver nitrate
3)Butyl chloride in 15% NaI-acetone
4) Butyl chloride in 1% ethanolic silver nitrate
5)Sec-butyl chloride in 15%NaI-acetone
6) Sec-butyl chloride in 1% ethanolic silver nitrate
7) Tert-butyl chloride in 15%NaI-acetone
8) Tert-butyl chloride in 1% ethanolic silver nitrate
9) Crotyl chloride in 15% NaI-acetone
10) Crotyl chloride in 1% ethanolic silver nitrate
Any help would be appreciated!
In what ways does an organization react to change? Under what
conditions are the members of an organization likely to embrace and
accept change? Under what conditions are they likely to resist
change?
Question about SN1 and SN2 reactions. In my lab we prepared
1-bromobutane from 1-butanol (SN2) and 2-chloro-2-methylbutane from
2-methyl-2-butanol (SN1). I don't undetstand the following
questions:
1. Why did we heat the SN2 reaction but not the SN1
reaction?
2. What was the purpose of performing a simple distillation on
both reactions? What were you isolating your products from?
3. What was the purpose of washing both of oyur reaction
mixtures with brine (saturated sodium chloride)?
What role does the leaving group play on the rate of
SN1 versus SN2 reactions? (compare 1-bromo to 1 chloro, 2-bromo to
2-chloro etc).What role does the structure of the substrates play
on the rate of SN1 versus SN2 reactions (compare primary,secondary
and tertiary that may have the same leaving group)
where is the chiral carbon located?
1.
Define and describe what is meant by Sn1 and Sn2.
2. Describe the differences between Sn1 and SN2 reactions,
including mechanistic details.
3. Discuss the difference between the intermediates for each
mechanisms- which you should draw.
1) Create a chart comparing E1, E2, SN1 and SN2 reactions. Be
detailed and cover: structure of RX, reactivity of nucleophile,
concentration of nucleophile, solvent and stereochemistry.
ORGANIC CHEMISTRY
experiment : Synthesis of n-butyl bromide (Sn2)
1.what is the function of the Hickman Still in this
experiment?
2. what is the function of the condenser in this experiment?
1.For both insulin and glucagon: Identify conditions under which
it will be present in the blood and describe outcomes of its
signaling on muscle, heart, liver and adipose tissue