The prelimbic cortex of the prefrontal cortex has glutamatergic projections to which regions involved in drug...

The prelimbic cortex of the prefrontal cortex has glutamatergic projections to which regions involved in drug addiction?

Select one:

a. nucleus accumbens and ventral tegmental area

b. nucleus accumbens

c. dorsal raphe nuclei

d. ventral tegmental area and dorsal raphe nucleus

e.
ventral tegmental area

Solutions

Expert Solution

Solution : Answer is option B; Nucleus accumbens.

The addiction towards drugs represents a dramatic downregulation of motivational and related circuits. Studies suggests that drug-induced re-establishment is mediated by the pathway that links the prelimbic prefrontal cortex to the ventral striatum . In studies on rats, neurotransmitter systems that are involved in drug-induced reestablishment comprise a glutamatergic projection from the prelimbic prefrontal cortex to the nucleus accumbens that is modulated through dopamine activity on specific D1 and D2 receptors in the frontal cortex

gladiator answered 2 years ago

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