Question

What are mechanism of action (whether significant or not) and all molecular actions of the Amlodipine?

Answer 1

Question : What are mechanism of action? (whether significant or not}

Answer :

In pharmacology, the term mechanism of action refers to the specific biochemical interaction through which a drug substance produces its pharmacological effect. A mechanism of action usually includes mention of the specific molecular targets to which the drug binds, such as an enzyme or receptor.

Why mechanism of action is important

By knowing the interaction between a certain site of a drug and a receptor, other drugs can be formulated in a way that replicates this interaction, thus producing the same therapeutic effects. ... It can help identify which patients are most likely to respond to treatment.

Mechanism of action is significant, Nevertheless, understanding a drug's mechanism could guide drug development and help to prevent late-stage failures such as Dimebon's. Knowledge of a drug's mechanism of action enables better dosing through monitoring of the drug's effects on the target pathway in the patient.

Question : molecular actions of the Amlodipine

Answer : Amlodipine is a synthetic dihydropyridine and a calcium channel blocker with antihypertensive and antianginal properties. Amlodipine inhibits the influx of extracellular calcium ions into myocardial and peripheral vascular smooth muscle cells, thereby preventing vascular and myocardial contraction. It is a peripheral arterial vasodilator that acts directly on vascular smooth muscle to cause a reduction in peripheral vascular resistance and reduction in blood pressure.