The major parts of the
digestive system:
- Salivary glands
- Pharynx
- Esophagus
- Stomach
- Small Intestine
- Large Intestine
- Accessory digestive organs: liver, gallbladder, pancreas
The major layers of the
gastrointestinal tract:
- inner layer
- lines the gastrointestinal tract
- simple columnar epithelilium
- blood vessels
- glands
- nerve plexuses (Meissner’s plexus)
- peristalsis
- nerve plexus (Myenteric plexus)
- Outer layer of connective tissue
Functions of the GI
system
- Motility: movement through the GI tract
- Digestion: breakdown of food or chyme
- Secretion and absorption: across and epithelial layer either
into the GI tract (secretion) or into blood (absorption)
- Storage and elimination:
- Esophagus and Stomach
Esophagus
- From pharynx to stomach
- Salivary glands release mucus for lubrication, antimicrobial
agents, and amylase to digest starch.
- epiglottis covers respiratory tract during swallowing
- At end of esophagus is the lower esophageal sphincter
(LES)
- Propulsion of food occurs through peristalsis: contraction
occurs behind the bolus of food and relaxation occurs ahead of the
bolus of food.
Stomach
Functions:
- store food
- initiate digestion of proteins
- kill bacteria with the strong acidity (low pH of the gastric
juice)
- make chyme
Parts of the
stomach:
- Fundus
- body
- pyloric region (pyloric sphincter)
- Material passed from the stomach to the small intestine is
called the chyme.
- The gastric glands of the stomach contain several types of
cells:
Cell Type
|
Secretions
|
Parietal cells
|
HCl; intrinsic factor
|
Chief cells
|
pepsinogen
|
Goblet cells
|
mucus
|
Enterochromaffin-like (ECL) cells
|
histamine;serotonin
|
D cells
|
Somatostatin
|
G cells
|
Gastrin
|
- pH of gastric juice is 2. The low pH of gastric juice:
- denatures ingested proteins
- optimum pH for pepsin activity is 2.0
- at pH 2.0, weak pepsinogen enzymes digest each other to form
pepsin
- The stomach digests only proteins, but not fats and
carbohydrates
- There is basically no absoprtion in the stomach
- Acid secretion by parietal cell:
H+ transport
- H+ is converted to CO2 (blood)
- CO2 diffused into parietal cell
- CO2 is converted back to H+
- H+ is transported into the GI lumen by a H+-K+-ATpase
Cl- transport
- Cl- is transported into the parietal by a Cl-/HCO3-
transporter
- Cl- diffused into the GI lumen via a Cl- channel
- Small Intestine
- small intestine is from the pyloric sphincter to the ileocecal
valve
- 12ft in length, small in diameter compared to large
intestine
- regions of the small intestine
- Duodenum: absoprtion of carbohydrates, lipids, amino acids,
Ca2+, iron
- Jejuneum: absopriton of carbohydrates, lipids, amino acids,
Ca2+, iron
- Ileum: absorption of bile salts, vitamin B12, water
electrolytes.
- Columnar epithelial cells
- Villi/ microvilli: increases surface area for absorption
- blood capillaries: absorption of monosaccharides, amino
acids
- lymphatic vessels (central lacteal): absorption of fats
- Brush border enzymes: dissacharidase, peptidase,
phosphatase.
Absorption in the Small
Intestine
Caloric content of food is derived
mainly from:
- carbohydrates (50%)
- proteins (11-14%)
- lipids (36%-39%)
Carbohydrates
Begins as starch (polysaccharide)
and then eventually digested into monosacharides for
absorption.
Amylase: Starch digestion begins in the mouth (salivary
amylase), and then continues in the duodenum (pancreatic amylase).
Amylase digestion of starch produces maltose (disaccharide) and
maltriose (trisaccharide) and oliosaccharides.
Brush border
enzymes: hydrolyze
maltose, maltriose, and oligosaccharides, sucrose, lactose to
monosaccharides for absorption.
The three absorbable
monosaccharides are glucose, galactose, and
fructose.
Transport across epithelial
layer
- Lumen side: Na+ cotransporter with monosaccharides
- Blood side: passive diffusion via a transporter
Proteins
Stomach:
Somewhat digested to short-chain
polypeptides by pepsin
Duodenum, jejunum:
Digested to amino acids, di-peptides,
tri-peptides by pancreatic juice enyzmes
Transport across epithelial
layer
- Lumen side: Na+ cotransporter with amino acids, di-peptides,
tri-peptides
- Blood side: passive diffusion via a transporter
Fats
Absorption of fats takes place in
the duodenum and are transported into the lymphatic
system.
- Fat droplets, mainly comprised of triglyerides are first
emulsified by bile salts (see later section for discussion of bile
salts). Emulsification makes the fat droplets smaller, making them
more easily digested enzymatically.
- Pancreatic lipase digests the smaller, emulsified fat droplets
into free fatty acids and monoglycerides.
- The free fatty acids and monoglycerides form micelles which
migrate towards the brush border membrane. The micelles contain
bile salts, lecithin, cholesterol and
- The free fatty acids and monglycerides leave the micelle and
enter the epithelial cell.
- Inside the epithelial cell the free fatty acids and
monoglycerides combine with protein to form chylomicrons (lipid +
proteins).
- The chylomicrons are secreted into the lymphatic system.
- Large Intestine
- large intestine is from the ileocecal valve to the rectum
- parts of the large intestine: ascending colon, transverse
colon, descending colon, sigmoid colon, , anal canal
- columnar epithelial cells, goblet cells, scattered lymphocytes,
lympathic nodules
- contains no villi
- involved in absorption of water, electrolytes, vitamins.
- Contains bacteria which serve a number of functions
- absorption of vitamins (B and K)
- produce small fatty acids used as energy by GI epithelial
cells
- help breakdown indigestible molecules
- final water content of feces is about 200 ml
Summary of Water transport in GI
tract
|
Amount of water
entering
|
Amount
reasborbed
|
Small Intestine
|
Ingestion: 1.5 liters
secretions: 7-9 liters
Total: 8.5-10.5 liters
|
6.5-9 liters
|
Large Intestine
|
1.5-2 liters
|
1.3-1.7 liters
|
|
200 ml
|
|
- Diarrhea is caused by many problems. The end result in a
decrease in water absorption, so the stools are very watery. This
can lead to severe dehydration.
- Cholera: Na+ secretion into GI lumen
- Celiac Sprue: damage to GI wall
- Lactose intolerance: osmolarity of the GI lumen
- Defecation reflex: opening of the external anal sphincter due
to pressure in the .
- Liver, Gallbladder and Pancreas
- Liver and Gallbladder
Anatomy
- Connected to gallbladder via bile duct and then to small
intestine
- Contains sinusoidal capillaries which are permeable to most
substances
- Unusual vasculature: G.I. capillaries ® Liver ® vena cava. This
allows filtration of ingested substances.
- Enterohepatic circulation: from liver via bile duct to small
intestine and then from small intestine back through portal vein to
liver
Major functions
- production and secretion of bile
- detoxication of blood
- secretion and storage of glucose
- production of albumin
Liver clears substances via the
bile duct in a similar manner to the way the kidney clears
substances into the nephron.
Production and secretion of
bile
- bile pigment or bilirubin: removes hemoglobin breakdown
products
- bile salts: adds in fat absorption
- phoshpholipids, cholesterol, inorganic ions.
Gallbladder stores bile. Bile
entering gallbladder is controlled by the sphincter of
Odii.
- Pancreas
Endocrine versus exocrine
function:
- endocrine: involves secretion into blood (inside the body,
endo): insulin and glucagons (endocrine function not discussed in
lecture)
- exocrine: involves secretion into GI system (outside the body,
exo).
Pancreatic juice
contains:
- water: H2O
- bicarbonate: HCO3-
- amylase: digests starch
- trypsin: digests protein
- lipase: digests fatty acids
- Control of the Digestive System
- Digestive system is controlled by:
- automatic activity
- autonomic nerves
- hormones
- Innervation of the gastrointestinal tract
- parasympathetic: rest and digest
- sympathetic: fight and flight
- enteric nervous system: intrinsic nervous system in GI
system
Autonomic Branch
|
Effect on GI
system
|
parasympathetic
|
motility, open valves
|
sympathetic
|
¯ motility, close valves
|
Three Phases in Control of
Gasric Function
- Cephalic Phase
- Gastric Phase
- Intestinal Phase
- Cephalic Phase:
Regulation by the vagus nerve:
lasts approximately 30 minutes.
The vagus nerve is activated by
sight, smell, taste of food.
Activation of the vagus
nerve:
- indirectly causes the parietal cells to secrete HCl
- directly stimulates chief cells to secreate pepsinogen to
digest proteins
- Gastric Phase
Stimulated by
- distension of the stomach (i.e. amount of chyme)
- chemical nature of the chyme
The goal of this phase is to
release acid and proteolytic enzymes into the stomach.
Feedback loops
- A positive feedback loop occurs in which peptides cause acid
and pepsinogen to be released and this in turn causes more peptides
in the stomach, which causes acid and pepsinogen to be released,
etc..
- A negative feedback loop occurs in which the low pH of the
stomach inhibits gastrin secretion by the G cells which results in
less acid secretion.
- Stimulation of HCl secretion:
- Vagus nerve and amino acids in the stomach lumen stimulate
gastrin release by G-cells
- Gastrin stimulates histamine release by ECL cells
- Histamine stimulates HCl secretion by parietal cells.
Stimulus for gastric
phase
- peptides (particularly phenylalanine and tyrptophan) stimulate
pepsinogen and acid secretion
- glucose and fats do not stimulate acid secretion.
- Intestinal phase
Inhibition of gastric activity due
to:
- neural reflex: stretch of the duodenum inhibits gastric
motility and secretion
- hormone: fat in the chyme stimulates an inhibitory hormone. It
is not clear what this hormone is. Potential candidates include
gastric inhibitory peptide, somatostatin, cholecystokinin,
glucagon-like.
Control of Intestine
- Chyme in duodenum stimulates
- gastric inhibition
- pancreatic secretion
- bile secretion
- Pancreatic juice secretion is controlled by secretin and
cholecystokinin (CCK).
- Secretin: stimulated by a drop in duodenal pH — results in
HCO3- secretion by pancreas and bile secretion
- Cholecystokinin: stimulated by fats and proteins in duodenum —
results in pancreatic secretion of enzymes and bile secretion.