Explain how Calcium can be absorbed from the digestive tract. What is Calcitriol?

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Answer

Calcium absorption

Calcium can be absorbed from digestive tract in two ways.
1) Passive transport or paracellular way
2) Active transport
In paracellular pathway, the increased concentration of calcium in gut is reponsible for the absorption. This is passive transport.
The high calcium concentration moves calcium molecules along their concentration gradient and alters the tight junctions making the tight junctions more permeable to the calcium.
Paracellular pathway takes place in jejunum and ileum parts when calcium intake is high.
In active transport, parathyroid hormone is reponsible for conversion of calcifediol to calcitriol.
Calcitriol acts on enterocytes lining the small intestine to increase the rate of calcium absorption.
Calbadin is a vitamin D dependent calcium binding protein that transfers the calcium to the endoplasmic reticulum of the enterocyte.
Calcium pumps are responsible for the active transport of calcium into the body.
Active transport of calcium mainly occurs in the duodenum of small intesitne.

Calcitriol

Calcitriol is the active form of vitamin D.
It is converted from calcifediol with the help of parathyroid hormone in kidneys.
Calcitriol is also known as 1,25-dihydroxycholecalciferol.
Calcitriol helps in calcium absorption from the small intestine.

Sydney Mullin answered 2 years ago

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