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In: Biology

how gene Gpr56 could be used to develop new treatment for myelin sheath disorders?

how gene Gpr56 could be used to develop new treatment for myelin sheath disorders?

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ANSWER:

Genetic defects that cause aberrant myeline development or degenerative disorder ar incompatible with a top quality of human life, however therapies that stop degenerative disorder and/or promote sturdy remyelination ar either inadequate or nonexistent. Here, we have a tendency to propose to see however the G protein-coupled receptor Gpr56 regulates myeline formation in development and myeline maintenance throughout adulthood.

Although myeline is needed for human life, the molecular mechanisms that underlie vegetative cell development and myelination ar incompletely understood. Previous studies indicate that animate thing matrix proteins and their receptors, additionally to animate thing signal transduction cascades, ar essential for correct development of myelinating interstitial tissue cells6–7. For this reason, adhesion G protein-coupled receptors (aGPCRs) represent sensible candidate regulators of vegetative cell development and myelination as a result of they're speculated to regulate each cell-cell and cell-matrix interactions further as signal transduction by heterotrimeric G protein 56, and up to date studies implicate aGPCRs as necessary regulators of myelination


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