Question

what is the role of a dna response element in inductive signaling?

Answer 1

DNA response elements are specific sequences that are present in promoters of genes that can bind to transcription factors or receptors, enhancing or inhibiting the response to that factor.

Inductive signaling is the influence of one signal from one cell that influences the development of another group of cells. In steroid hormones signaling, the steroid hormones are released by a different cell types. They are secreted in circulation and arrive at the target organs. Steroid hormones can bind to their receptors in either the membrane or cytoplasm, as they can cross the cell membrane. The receptor dimers and will enter the nucleus. The DNA binding domains will then bind to the DNA response elements (Steroid response element) on the specific target genes and increased the expression of these genes.

Inducing cells also produce ligands or transmembrane that induce signaling in other cells. For example, the Notch ligand expressed by one cell, delta or jagged will bind to any of the four Notch receptors (1-4) on other cell. This results in cleavage of the Notch receptors by gamma secretase enzyme. The intracellular domain of the Notch receptor, enters the nucleus and binds to specific DNA response elements present in the promoter of target genes. As a result, the transcription of target genes is enhanced. Notch signaling plays an important role in Drosophila embrogenesis.