1. What are secreted proteoglycans found in the extracellular matrix? a. they are proteins covalently linked...

1. What are secreted proteoglycans found in the extracellular matrix?

a.	they are proteins covalently linked to any polysaccharides

b.	they are proteins covalently linked to fibronectin fibrils

c.	they are proteins covalently linked to any oligosaccharides

d.	they are proteins covalently linked to collagen fibrils

e.	they are proteins covalently linked to glycosaminoglycans

2. Which of the following signaling molecule is first produced upon activation of olfactory receptor neurons to mediate "smell"?

a. DAG

b. cAMP

c. IP3

d. cGMP

e. PIP3

Solutions

Expert Solution

1) Proteoglycans are proteins in which the central protein core is linked to O-linked glycosaminoglycan side-chains. They can be divided into two classes —

a) The large proteoglycans: example aggrecan of cartilage

b) The small proteoglycans : example decorin, biglycan, fibromodulin, lumican, and mimican present in equine tendon.

The large proteoglycans have many highly sulfated glycosaminoglycan side-chains. These side chain forms interaction with water. The small proteoglycans are closely associated with the collagen fibrils. They regulate collagen fibril diameters.

Right option is e.

2) Olfactory receptor neurons are positioned within the nasal epithelium. Their processes extend across the mucosal surface. The receptor is a G protein-coupled receptor present in the sensory cilia. It is activated by odorant ligands leading to activation of G protein, Golf. This stimulates adenylyl cyclase III (ACIII) to synthesize cAMP. Increased intracellular cAMP opens a cyclic nucleotide-gated (CNG) channel. As a result, there is an influx of sodium and calcium ions causing depolarization of the neuron. The initial depolarization activates o calcium-activated chloride channels. There is and, efflux of Cl− from the cell. The depolarization in the olfactory cilia opens voltage-sensitive ion channels in the sensory neuron's axon hillock, resulting in the firing of action potentials. Neurotransmitter is released in the synaptic terminal in the olfactory bulb.

Right option is b. cAMP

gladiator answered 1 year ago

Next > < Previous

Related Solutions

1. The extracellular matrix (ECM) was regarded decades ago as an uninteresting set of proteins and...

1. The extracellular matrix (ECM) was regarded decades ago as an uninteresting set of proteins and unusual carbohydrates that were required for cell adhesion and tissue integrity. Now, however, there is much more of an interest in the ECM given its importance in cancer and metastasis - a concept that is embodied in the phrase, "tumor microenvironment". a. What is the importance of E-cadherin? b. Collagen synthesis is unique given its final assembly stage. Explain this statement. c. Challenge: You...

1. if you think of the extracellular matrix (ECM) as a fiber-reinforced matrix, which of the...

1. if you think of the extracellular matrix (ECM) as a fiber-reinforced matrix, which of the following are the fiber forming elements? (choose as many as apply) a. elastin b. glycoproteins c. proteoglycans d. collagen 2.if you had to perform an experiment where you had to evaluate cytotoxicity, which of the following assays would be options to consider. (choose as many as apply) a. western blot b. PCR c. MTS assay d. RT-PCR e. MTT assay f. northern blot g....

72.Diversity and functions of proteins of extracellular matrix. -biochemistry (please more explanatıon Im medicine student) thank...

72.Diversity and functions of proteins of extracellular matrix. -biochemistry (please more explanatıon Im medicine student) thank you...

A detailed explanation of the role of the Extracellular Matrix?

Give a short and concise answer. What is an extracellular matrix, and what role does it...

Give a short and concise answer. What is an extracellular matrix, and what role does it play in wounds and healing of wounds?

what role does the extracellular matrix play in the process of wound healing?

Where are protein components of the extracellular matrix synthesized? A.at the rough ER B.in the extracellular...

Where are protein components of the extracellular matrix synthesized? A.at the rough ER B.in the extracellular layer itself C.in the plasma membrane D.in the Golgi apparatus

1. What type of proteins are often found in lipid rafts? a. Peripheral membrane proteins b....

1. What type of proteins are often found in lipid rafts? a. Peripheral membrane proteins b. GPI-anchored proteins e.g. proteins involved in signaling c. Enzymes 2. During the “green revolution” a wheat mutation was identified in the gene rht1. The wild-type RHT1 protein turned out to be a protein that has a DELLA domain. The rht1 mutant wheat protein was found to lack a DELLA domain. What was the effect of this rht1 mutant protein in regards to GA signaling?...

Describe six different molecules that compose the extracellular matrix.

Antibodies are proteins that are secreted out of the cell. If an NLS was genetically engineered...

Antibodies are proteins that are secreted out of the cell. If an NLS was genetically engineered to the C-terminus of an antibody, where do you expect to find it? a. Outside the cell b. ER c. Cytoplasm d. Nucleus e. Another organelle Can you please explain the question too. Thanks

Subjects