Question
In: Chemistry
12. a) Consider a sample of hemoglobin molecules all bound to carbon monoxide CO. What conformation...
12.
a) Consider a sample of hemoglobin molecules all bound to carbon monoxide CO. What conformation would be favored? What would the Hill plot of that sample look like?
b Consider a sample of hemoglobin molecules all bound to BPG. What conformation would be favored? What would the Hill plot of that sample look like?
Solutions
Expert Solution
a). Hemoglobin (Hb) contains four heme units (tetramer)and four globular proteins sub-units.
Hb has two histidine group one is DISTAL and another one PROXIMAL. Hence, histidine group (DISTAL) situated near Iron and assisted the binding of dioxygen in "end-on-bent" conformation, this particular bent discourage the binding of carbon monoxide (CO) to haem iron.
If Hb molecules bound to CO then CO-Hb referred to as T-state (Tense) of Hb at low pH.
b) Bisphosphoglycerate (BPG) reduces the affinity of Hb with oxygen it binds between two beta units of Hb where it stabilizes the T-state into R-state (relax) of Hb, at high pH.it also observed that at high altitude (mountains) the amount of BPG increases in blood.it does not affect the affinity of the affinity of Hb with oxygen in lungs but decrease the affinity in tissues.
queen_honey_blossom answered 1 year agoRelated Solutions
1. Hemoglobin binds to and has a much higher affinity for carbon monoxide (CO) than for...
1. Hemoglobin binds to and has a much higher affinity for carbon
monoxide (CO) than for oxygen. CO is colorless and odorless and can
be produced in homes heated by natural gas; victims usually do not
realize they are being poisoned and often die in their sleep.
Describe the likely changes in a CO poisoning victim.
2. You are a physiologist on a space flight to a distant planet.
You discover intelligent humanoid aliens inhabiting the planet, and
they willingly...
A 0.020 mol sample of carbon monoxide (CO) is placed in a cylinder fitted with a...
A 0.020 mol sample of carbon monoxide (CO) is placed in a
cylinder fitted with a movable frictionless piston. This gaseous
sample - initially at volume Vi = 4.00 L - has a
pressure of 0.400 atm - identical to the external pressure. This
gaseous sample then undergoes a cyclic
process. Throughout the cyclic process, the sample is thermostatted
at a Kelvin temperature T. The details of this cyclic process:
First, a two-step expansion carried out as
follows:
The...
Consider the decomposition of acetaldehyde (CH3CHO) into methane (CH4) and carbon monoxide (CO).
Consider the decomposition of acetaldehyde (CH3CHO)
into methane (CH4) and carbon monoxide (CO).CH3CHO → CH4 + COAn experiment is performed where the concentration of
acetaldehyde is measured at various time intervals, resulting in
the following data.Time (s)[CH3CHO] (M)0.00.24220.00.16840.00.12960.00.104(a) Using Excel (or similar software), graph the three types of
plots outlined below and enter the slope, y-intercept, and
R2 for each graph). Use the graph with the best linear
fit to determine the order of the reaction with respect to
CH3CHO....
Carboxyhemoglobin is formed when hemoglobin is exposed to carbon monoxide. Heavy smokers tend to have a...
Carboxyhemoglobin is formed when hemoglobin is exposed
to carbon monoxide. Heavy smokers tend to have a high percentage of
carboxyhemoglobin in their blood.† Let x be a random
variable representing percentage of carboxyhemoglobin in the blood.
For a person who is a regular heavy smoker, x has a
distribution that is approximately normal. A random sample of
n = 12 blood
tests given to a heavy smoker gave the following
results (percent carboxyhemoglobin in the blood). Note: For
degrees of...
Select the MOST CORRECT answer. Carbon dioxide is transported in the blood mostly bound to hemoglobin...
Select the MOST CORRECT answer.
Carbon dioxide is transported in the blood mostly bound to
hemoglobin or dissolved in plasma.
Hemoglobin has a higher affinity for oxygen than myoglobin,
allowing a fairly rapid movement of oxygen from muscle to plasma
during exercise.
Bicarbonate ion is pumped into and out of the red blood cell by
a chloride antiporter.
Both a) and b) are correct and c) is incorrect.
a), b) and c) are all correct.
Select the MOST CORRECT answer....
Discuss the impact to hemoglobin structure/function from exercise, high altitude, carbon monoxide, carbon dioxide, 2, 3...
Discuss the impact to hemoglobin structure/function from
exercise, high altitude, carbon monoxide, carbon dioxide, 2, 3 BPG,
etc.
The relationship between the amount of remaining carbon monoxide (CO) in an individual’s lungs and the...
The relationship between the amount of remaining carbon monoxide
(CO) in an individual’s lungs and the time since that person last
smoked a cigarette can be summarized using a linear regression
approach.
(a) Write down a simple linear regression model and the
underlying assumptions. The following summary data was collected
from 12 different smokers. x = time since last smoked a cigarette
(hours) y = amount of CO in ppm n=12, x=1.88 sxx =25.8, syy =1805
SSE=877.4 Fitted regression line:...
The relationship between the amount of remaining carbon monoxide (CO) in an individual’s lungs and the...
The relationship between the amount of remaining carbon monoxide
(CO) in an individual’s lungs and the time since that person last
smoked a cigarette can be summarized using a linear regression
approach.
(a) Write down a simple linear regression model and the
underlying assumptions. The following summary data was collected
from 12 different smokers.
x = time since last smoked a cigarette (hours) y = amount of CO
in ppm
n=12, x=1.88 sxx =25.8, syy =1805 SSE=877.4 Fitted regression
line:...
The relationship between the amount of remaining carbon monoxide (CO) in an individual’s lungs and the...
The relationship between the amount of remaining carbon monoxide
(CO) in an individual’s lungs and the time since that person last
smoked a cigarette can be summarized using a linear regression
approach.
Write down a simple linear regression model and the underlying
assumptions. The following summary data was collected from 12
different smokers.
x = time since last smoked a cigarette (hours) y = amount of CO
in ppm
n=12, x=1.88 sxx =25.8, syy =1805 SSE=877.4 Fitted regression
line: ?̂...
5. Consider the combustion of carbon monoxide (CO) in oxygen gas: 2CO(g) + O2(g) → 2CO2(g)...
5. Consider the combustion of carbon monoxide (CO) in oxygen
gas: 2CO(g) + O2(g) →
2CO2(g)
A. Calculate the number of moles of CO2 produced if
2.86 moles of CO is reacted with excess oxygen._______ moles
CO2.
B. Determine the moles of oxygen required to react with the
CO._______ moles O2
6. Consider the following balanced chemical equation:
C2H5OH(l) +
3O2(g) → 2CO2(g) +
3H2O(l)
a. How many moles of CO2 form when 1.73 moles of
C2H5OH react? ______ moles...
ADVERTISEMENT
ADVERTISEMENT
Latest Questions
- Ocean park SWOT on leadership style - Strength - Weakness - Opportunities - Threats
- C LANGUAGE ONLY Write a C program to count the total number of duplicate elements in...
- Ted Mosby is a professor at Columbia University where he teaches architecture. Although Ted enjoys his...
- Problem 23-4A (Part Level Submission) Kansas Company uses a standard cost accounting system. In 2017, the...
- In C# Create a windows application which accepts the month number and displays the month name...
- You have been given a piece of steel but you do not know its composition. Describe...
- Requirements How can management be modelled to enhance food security entrepreneurship in rural Zambia? What must...
ADVERTISEMENT