True/False: There are usually less mutations near the transcription start site of the variable region for...

True/False: There are usually less mutations near the transcription start site of the variable region for an antibody.

Which of the following is most analogous (or most closely matches) to the germinal center in the secondary lymphoid tissue?

a. the cortex of the thymus

b. the spongy tissue of the bone

c. the medulla of the thymus

d. the plasma of the bone marrow

Which of the following is not part of the T-cell receptor complex?

a. alpha chain

b. CD3 complex

c. beta chain

d. IgA

Solutions

Expert Solution

1. False,
as there are reatively large mutations near transcription start site of variable region of an antibody
a somatic process can induce mutations into antibody variable region at a high rate in vertebrates and leads to antibody diversity.
2. Most analogous to germinal center in secondary lymphoid tissue is the cortex of thymus
as cortex of thymus produce hormones that hep in growth and differentiation of T cell progenitors.
similarly germinal centers are place where mature B cells proliferate,differentiate and mutate their antibody genes.

3. IGA
IGA is not a part of TCR as TCR is disulfide linked menbrane anchored heterodimeric protein normally consisting of alpha and beta chains expressed as a part of complex with the invariant CD3 chain molecules

gladiator answered 1 year ago

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