consider the conversion of glucose to lactate by glycolysis. Determine number of ATP, NADH, and FADH2...

consider the conversion of glucose to lactate by glycolysis. Determine number of ATP, NADH, and FADH2 produced by this rxn sequence.

Solutions

Expert Solution

In humans, aerobic conditions produce pyruvate and anaerobic conditions produce lactate.

In aerobic conditions, the process converts one molecule of glucose into two molecules of pyruvate (pyruvic acid), generating energy in the form of two net molecules of ATP. Four molecules of ATP per glucose are actually produced, however, two are consumed as part of the preparatory phase.

Glucose + 2 NAD⁺ + 2 P_i + 2 ADP → 2 pyruvate + 2 NADH + 2 ATP + 2 H⁺ + 2 H₂O

Krebs cycle contributes 4 more carbon dioxide molecules, 6NADH, 2 FADH2 and 2 ATP.

During anaerobic glycolysis, NAD+ regenerates when pairs of hydrogen combine with pyruvate to form lactate

2 pyruvate + 2 NADH + 2 H+ → 2 NAD⁺ + 2 lactate

Overall reaction of anaerobic metabolism:

Glucose + 2 P_i + 2 ADP → + 2 lactate + 2 ATP + 2 H₂O

queen_honey_blossom answered 1 year ago

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