Question
In: Biology
It has been demonstrated that some people treated with statins show an increased accumulation of lipids...
It has been demonstrated that some people treated with statins show an increased accumulation of lipids in the liver and skeletal muscles, as well as a mitochondrial dysfunction in skeletal muscles.
Explain why statin treatment results in lipid accumulation in the liver and in the skeletal muscle.
Solutions
Expert Solution
Before getting the answer you should know what actually is Statin Treatment.
Statin Treatment is the consuming of statin drug for lowering LDL cholesterol and prevents coronary heart diseases, heart attacks, strokes etc. It includes various drugs namely Pravastatin (Pravachol) and lovastatin (Altoprev) which are considered among the best drugs.
As we all know like every coin has two faces, Statin Treatment comes with side effects too.
People treated with statins show an increased accumulation of lipids in the liver and skeletal muscles, as well as a mitochondrial dysfunction in skeletal muscles. Statin increased their intracellular content of LDs in both non-malignant as well as cancer cells. Now there are two reason for the same:
- due to the uptake of cholesterol and triacylglyceroles from medium
- due to enhanced synthesis of triacylglyceroles
Therefore it led to accumulation of cytosolic LDs within the examined cells, a phenomenon which might contribute to the antiproliferative effects of statins.
gladiator answered 2 years agoRelated Solutions
It has been demonstrated that some people treated with statins show an increased accumulation of lipids...
It has been demonstrated that some people treated with statins
show an increased accumulation of lipids in the liver and skeletal
muscles, as well as a mitochondrial dysfunction in skeletal
muscles. Explain why statin treatment results in lipid accumulation
in the liver and in the skeletal muscles
It has been demonstrated that some people treated with statins show an increased accumulation of lipids...
It has been demonstrated that some people treated with statins
show an increased accumulation of lipids in the
liver and skeletal muscles, as
well as a mitochondrial dysfunction in skeletal
muscles. Explain why statin treatment
results in lipid accumulation in the liver and in the
skeletal muscle.
What other metabolite accumulates explaining why there is
increased fatty acid synthesis if HMG-CoA (due to statin treatment)
accumulates in the cytosol and slows downs the cholesterol
synthesis pathway.
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