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It has been demonstrated that some people treated with statins show an increased accumulation of lipids...

It has been demonstrated that some people treated with statins show an increased accumulation of lipids in the liver and skeletal muscles, as well as a mitochondrial dysfunction in skeletal muscles.

Explain why statin treatment results in lipid accumulation in the liver and in the skeletal muscle.

Solutions

Expert Solution

Before getting the answer you should know what actually is Statin Treatment.

Statin Treatment is the consuming of statin drug for lowering LDL cholesterol and prevents coronary heart diseases, heart attacks, strokes etc. It includes various drugs namely Pravastatin (Pravachol) and lovastatin (Altoprev) which are considered among the best drugs.

As we all know like every coin has two faces, Statin Treatment comes with side effects too.

People treated with statins show an increased accumulation of lipids in the liver and skeletal muscles, as well as a mitochondrial dysfunction in skeletal muscles. Statin increased their intracellular content of LDs in both non-malignant as well as cancer cells. Now there are two reason for the same:

  1. due to the uptake of cholesterol and triacylglyceroles from medium
  2. due to enhanced synthesis of triacylglyceroles

Therefore it led to accumulation of cytosolic LDs within the examined cells, a phenomenon which might contribute to the antiproliferative effects of statins.

gladiator answered 2 years ago
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