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In: Statistics and Probability

A study was conducted concerning the effect of calcium supplementation on bone loss among postmenopausal women....

A study was conducted concerning the effect of calcium supplementation on bone loss among postmenopausal women. Women were randomized to 3 groups:

  1. estrogen cream and calcium placebo (n=15),
  2. placebo estrogen cream and 2000 mg/day of calcium (n=15), or
  3. placebo estrogen cream and calcium placebo (n=13).

Subjects were seen every 3 months for a 2-year period. The rate of bone loss was computed for each woman and expressed as a percentage of the initial bone mass. The mean (+/- 1 sd) of total-body bone mass (percentage per year) in the three treatment groups are shown in the table below.

Estrogen (n=15) Calcium (n=15) Placebo (n=13)
-0.43 +/- 1.60 -2.62 +/- 2.68 -3.98 +/- 1.63

Conduct a pairwise comparison to compare the Estrogen Group (1) to the Calcium Group (2). Report a p-value (correct to 3 decimal places), using the Least Significant Difference method.

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orchestra answered 1 year ago
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