Question

Compare and contrast the different types of inhibitors, with examples, including: transition state inhibitors, suicide inhibitors, irreversible inhibitors, competitive and noncompetitive inhibitors

Answer 1

The transition state inhibitars binds to the active site of the enzyme in the enzyme catalysed reaction . As the enzyme 's active site location is occupied by the inhibitors and there are very less enzyme available for the catalystsation reaction. The rate of reaction decreses examples are :- Neuraminidase inhibitor, sequinavir that is used in HIV treatment .

Suicide inhibition is an example of irreversible inhibition in which the inhibitors takes part in the reaction and convert into more potent inhibitor and inhibit the cataysis of reaction example :- asprin in high doses.
Irreversible inhibitors or the non competitive inhibitors are generally heavy metals oxidising agent . They bind to the enzyme other than active site and inhibits the process of catalysis . Increasing the concentration of substrate has no effect on the rate of catalysis examples are cyanide , fluoride , british anti lewisite .
Incompetitive inhibition , the inhibitor binds to the active site of the enzyme and there is a competition between enzyme and inhibitors for binding with active site of enzyme . The rate of reaction increases on increasing the substrate concentration example :- malonate is the inhibitor of succinyl dehydrogenase .

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