Sickle cell disease (SCD) is found in numerous populations whose ancestral homes are in the malaria...

Sickle cell disease (SCD) is found in numerous populations whose ancestral homes are in the malaria belt of Africa and Asia. SCD is an autosomal recessive disorder that results from homozygosity for a mutant β-globin gene allele. Data on one affected population indicates that approximately 16 in 100 newborn infants have SCD.

Part A

What is the frequency of the wild-type (β^A ) allele in this population?

Express your answer using two decimal places.

Part B

What is the frequency of the mutant (β^S ) allele in this population?

Express your answer using two decimal places.

Part C

What is the frequency of carriers of SCD in the population?

Express your answer using two decimal places.

Solutions

Expert Solution

gladiator answered 1 year ago

Next > < Previous

Related Solutions

What is the pathophysiology of acute sickle cell disease (SCD) crisis and why is pain the...

What is the pathophysiology of acute sickle cell disease (SCD) crisis and why is pain the predominate feature of acute crises? Explain the genetics of hemophilia Describe the pathophysiology of hydrocephalus in infants with myelomeningocele. How does lead poisoning account for the child’s symptoms? What is thought to be the pathophysiology of idiopathic scoliosis?

sickle cell distribution compared to malaria distribution

Describe the pathophysiology of sickle cell disease.•Discuss factors that can precipitate a sickle cell crisis.•Create a...

Describe the pathophysiology of sickle cell disease.•Discuss factors that can precipitate a sickle cell crisis.•Create a care plan for the patient presenting in sickle cell crisis.•Prioritize assessments and interventions for thepatient in sickle cell crisis.•Discuss the rationale for common medications and interventions used to treat sickle cell crisis.•Discuss pain management recommendations for the patient in sickle cell crisis.•Create an education plan for the patient being discharged following hospitalization for sickle cell crisis.•Describe common complications of sickle cell disease.•Discuss the rationale...

A group of African children were tested for both sickle-cell and malaria. Out of the whole...

A group of African children were tested for both sickle-cell and malaria. Out of the whole group, 23% had sickle-cell, 35% had malaria, and 6% had both. (a) Use a contingency table to structure the above information about the incidence of sicklecell and malaria among these children. Complete all marginal totals as well as the body of the table. [4] (b) What proportion of children with malaria also had sickle-cell? [2] (c) Among children who had sickle-cell, what proportion did...

1- Patients with sickle-cell disease and those with sickle-cell trait differ greatly in clinical presentation. List...

1- Patients with sickle-cell disease and those with sickle-cell trait differ greatly in clinical presentation. List at least two features in clinical presentation, and explain why they differ. 2- Other than hemoglobin S, name two abnormal hemoglobins that produce a positive sickle solubility test. Explain how they could be differentiated from HbS. 3- Explain how methemoglobin is formed, and how its presence impacts oxygen delivery. Be sure to include oxygen affinity in your answer. 4- How is methemoglobin detected in...

The frequency of the sickle cell allele is high in populations at low elevations in East...

The frequency of the sickle cell allele is high in populations at low elevations in East Africa, where mosquitos breed year-round, and lower in high elevation populations where mosquitos are much less abundant. Which, if any, evolutionary processes might contribute to these differences in allele frequencies? Explain your answer.

The nurse is caring for a patient with exacerbation of sickle cell disease and in pain...

The nurse is caring for a patient with exacerbation of sickle cell disease and in pain crisis due to an infection. When reviewing the lab values, the nurse would anticipate which of the following lab values? Select all that apply. 1. Reticulocyte 12% 2.Hgb 9.2 mg/dL. 3.WBC 14.3x 103\microL 4. Ca 4.9 mg/dL

Provide Health Promotion teaching with references for Sickle Cell Disease.

Explain how the sickle cell mutation results in the symptoms of the disease?

Sickle-cell anemia is an autosomal recessive disease, people with the disease have a ss genotype and...

Sickle-cell anemia is an autosomal recessive disease, people with the disease have a ss genotype and people without the disease have a SS genotype. People who have the disease get very ill, but people who have only one copy of the recessive gene are actually protected from getting malaria (Ss heterozygote genotype). Which area of the world is the frequency of sickle cell anemia the highest? Why do you think this is true (related to heterozygote advantage)? We talked about...

Subjects