Question

In: Chemistry

what are the starting reactants and final products of TCA Cycle....the number of coenzyme reduced and...

what are the starting reactants and final products of TCA Cycle....the number of coenzyme reduced and where it occurs

Solutions

Expert Solution

The starting material of the TCA cycle is acetyl coA NAD+, FAD, ADP, Pi and 3H2O.

The final products of the TCA cycle are carbon dioxide, reduced coenzymes (FADH2 and 3NADH) and ATP.

Reaction :

Acetyl CoA + 3NAD+ + FAD + ADP + Pi + 3H2O ----> 2CO2 + CoA + FADH2 + 3NADH + ATP + 3H+

The number of coenzymes reduced/one cycle in mitochondrial matrix :

a) NAD+ ----> NADH - 3

b) FAD -----> FADH2 - 1

Ubiquinone (Q) ----> Reduced Ubiquinone (QH2)

Reactions are :

Isocitrate + NAD+ -----> alpha ketoglutarate + NADH

alpha ketoglutarate + NAD+ ----> succinyl coA + NADH

Succinyl coA + ADP ----> Succinate + ATP

Succinate + FAD ----> Fumarate + FADH2

Malate + NAD+ ----> oxaloacetate + NADH


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