Why is the coagulase test important in diagnosing infections with Staphylococcus? How does the production of...

Why is the coagulase test important in diagnosing infections with Staphylococcus? How does

the production of coagulase benefit a species of Staphylococcus in causing an

infection?

Expert Solution

Ans- coagulase testing is the single most reliable method for identifying staphylococcus aureus .Staph Staphylococcus aureus produces free coagulase , staphylococcus epidermis does not . The coagulase test is useful for differentiating potentially pathogenic staphyStaphylo . Such as staphylococcus aureus from other gram positive , catalase positive coagulase . Production can be detected uaing either the slide coagulase test ( SCT ) or tube coagulase test ( TCT).

Clinical isolates of the human pathogens Staphylococcus aureus secrete coagulase( coa), a polypeptide that binds to and activates prothrombin , thereby convert fibrinogen to fibrin and promoting clotting of plasma and blood. The fibrin clot may protect the bacterium from phagocytosis and isolate it from other defenses of the host . The fibrin coat can therefore make the bacteria more virulent and helps staphylococcus in causing infection.

gladiator answered 1 year ago

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