7. What are the different concerns about off-target edits by CRISPR-Cas when editing the human genome...

7. What are the different concerns about off-target edits by CRISPR-Cas when editing the human genome in embryos versus adult somatic cells?

Expert Solution

when the gene is edited in the the somatic cell of an individual by CRISPR- Cas method, then it is found to be the restricted action in the somatic cell of a particular region in the body only. The whole individual do not Express such genes. And it cannot pass the the gene to the offspring.

But when the gene is edited in the embryonic stages, then the gene is found in all cells of the body. Because embryo will divide further to produce whole individual. That's why the modified cells are found in the whole body parts. It is also expressed in germ cell region. That's why an individual can pass the genes to the next generation too.

gladiator answered 2 years ago

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