Question

how it impacts the Amyloid plaques

Answer 1

Impact of amyloid plaques:

Amyloid plaques are a collection of protein which altered structural intergrity.This plaques are a characteristic in the development of Alzheimer's disease.The aggregation of these proteins in the cortical region of the brain play a profound role in the development of Alzheimers disease.

Usually, and secretase which are the enzymes which are involved in the breakdown of amyloid precursors and make these precursors into a soluble form so that they are not formed into the plaques.

But in case of Alzheimer's Disease, an enzyme secretase comes into play which it gets complex with the secretase to form an insoluble mass or monomer called the amyloid monomer.This formed monomer then binds to the exterior of the neurons and leads to the development of amyloid plaques.This again will result in the hindering of the neuronal signaling and impairs cognition.