Question

One page ( on Word, 400 words) summary of the Nobel Prize in Physiology or Medicine at 2012

Please dont send in a hand-written picture.. they are hard to read.

Answer 1

Nobel Prize in Physiology or Medicine is awarded for a discovery or invention that already is improving the practice of medicine and saving lives. But in 2012 the nobel prize given for very basic research that might someday affect medical practice and human health. 2012 nobel awarded to Sir John Gurdon of Great Britain and Dr. Shinya Yamanaka "for the discovery that mature cells can be reprogrammed to become pluripotent."

If I had to put into one sentence the message of 2012 medicine nobel Prize, it would be this: our cells are a lot smarter and more flexible than we once imagined, and capitalizing on that fact could greatly improve the treatment of many human diseases.

Each of us begins with the fusion of an egg and a sperm, which form a single cell. That one cell multiplies into trillions of cells. But the cells don’t just multiply. They also diversify. The primitive cells in first days of life can change into the many different types of specialized cells that we need.Each type of cell looks different and acts different, yet each has exactly the same genes inside it.Formar biology researchers taught cells could diversify in only one direction: primitive cells could become specialized cells, but specialized cells couldn’t turn into other specialized cells, or turn back into primitive cells.

John Gurdon published a paper in 1960s that astonished biologists. Indeed, many didn’t believe it. He took the nucleus out of a specialized cell from an adult frog. Call it Frog A. Then he took an egg from Frog B, removed the nucleus from that egg, and inserted the nucleus from the specialized cell of Frog A. The Frog B egg, with its new Frog A nucleus, turned into a tadpole and then a frog like Frog A.

Gurdon had made a clone, an exact genetic replica, of Frog A—just younger. He had shown that the genes in the nucleus of a specialized adult cell could be coaxed back into becoming an unspecialized, primitive cell, and that the primitive cell could become a young animal that grew up to become an adult, full of specialized cells. Gurdon had started the cycle of life all over again. He had turned back the clock—at least, in a frog. Very few people believed that anything like this could be done in humans.

In early 21st century. Human embryonic stem cells had been discovered. In the test tube, they could be turned into many different types of specialized cells. That was exciting, because many diseases involve the death of cells. What if you could replace the dead cells with new cells made from embryonic stem cells?

While the prospect was exciting, there were two big problems. First, many people had serious ethical concerns about using stem cells taken from human embryos. Second, if you needed new cells—new heart muscle cells to replace cells killed by a heart attack, for example—they would have to come from an embryo that was genetically different from you. That meant that your immune system would attack those foreign heart muscle cells.

What you really would like were heart cells made from your own embryonic stem cells. Unfortunately, the embryo that was you is, of course, long gone, and you can’t turn back the clock.

But John Gurdon had turned back the clock. Enter Shinya Yamanaka, a young Japanese scientist. Fine scientists answer questions posed by others.Yamanaka asked just two questions.

Question one: since embryonic stem cells and specialized cells have exactly the same genes inside them, what makes them different? Certain genes must be turned on in embryonic stem cells that are not turned on in specialized cells. What are they?

Humans have about 21,000 genes. To his great surprise, Yamanaka found that a handful were turned on in stem cells but not in many different types of specialized cells.

Question two: what would happen if you took the genes that are activated in an embryonic stem cell and placed them, in activated form, inside a specialized cell? Could you turn a specialized cell back into the equivalent of your own embryonic stem cell? Could you make specialized adult human cells turn back the clock, just as Gurdon had done with frogs?

Yamanaka created cells very much like embryonic stem cells, called induced pluripotent stem cells (iPS). Scientists quickly showed that you could create for mice their own iPS cells, and that these cells could then go on to cure diseases—for example, mouse equivalents of sickle cell disease and Parkinson’s disease.

Of course, much more study of these iPS cells is necessary before they are considered for the treatment of human diseases.The 2012 Nobel Prize in Medicine, demonstrates people with the curiosity and courage with a society that supports their work, can change our world for the better place.