Question

In: Biology

A) Six different mutations were derived from base pair substitutions at a single codon. In this...

A) Six different mutations were derived from base pair substitutions at a single codon. In this codon, the mutant alleles had asparagine, glutamic acid, g;lutamine, methionine, arginine, and a stop codon. What was the wild-type codon?

Solutions

Expert Solution

Methionine is encoded only by ATG.

Asparagine is encoded by AAT, AAC

Glutamic acid is encoded by -GAA, GAG

Arginine is encoded by - CGT, CGC, CGA, CGG; AGA, AGG

Glutamine is encoded by - CAA, CAG

Stop codon - TAA, TGA, TAG

If we at most to the codon then the last base is G.

Hence the last base is __G in the codon.

If we look at most of the codon such as AAT, AAC, GAA, GAG, CAA, CAG and TAG, Adenine is present in the middle of the codon.

So the codon is _AG.

If we look at most of the codon such as AGA, AGG, ATG, AAT, AAC, AGA, AGG Adenine is present in the first position of the codon. So the codon is AAG.

AAG can be mutated to - ATG - methionine

AAG can be mutated to AGG - arginine.

AAG can be mutated to CAG -Glutamine

AAG can be mutated to GAG - Glutamic acid

AAG can be mutated to AAT or  AAC - Asparagine.

AAG can be mutated to TAG - stop codon.

Hence the wild-type codon is AAG.

Please write to me if you need more help.


Related Solutions

In a particular gene in mice, a single base pair change from GC to an AT...
In a particular gene in mice, a single base pair change from GC to an AT at the 5’ end of the first intron causes a longer transcript to be made as well as a non-functional gene product. When such a mutation is present in both copies of this gene in a mouse, the mouse shows a mutant phenotype. Propose a molecularly based explanation for how such a single base change at the start of an intron could specifically result...
QUESTION 1 A single base change mutation at the third position in a codon for a...
QUESTION 1 A single base change mutation at the third position in a codon for a protein encoding gene would most often cause a ______. ( ) Deletion mutation ( ) Insertion mutation ( ) Nonsense mutation ( ) Silent mutation ( ) Missense mutation 3 points   [Save Answer] QUESTION 2 Which of the following correctly ranks a point mutations effect on a protein from most severe mutation to the least? ( ) Missense, silent, nonsense ( ) Silent, nonsense,...
13. A) A change to a single base pair in the sequence of a DNA molecule...
13. A) A change to a single base pair in the sequence of a DNA molecule is called a ______ mutation. B) If that single nucleotide change results in a protein with the exact same amino acid sequence it is called a _________ mutation. C) If the base pair change results in an alteration of the amino acid sequence of the protein it is called a ___________ mutation. D) If the base pair changes results in a codon for an...
How can mutations in different genes be associated with a single disease?
How can mutations in different genes be associated with a single disease?
A single substitution mutation has altered a codon from an “AGU” to an “AGC”. What effect...
A single substitution mutation has altered a codon from an “AGU” to an “AGC”. What effect will this have on the protein? 1. This would be a missense mutation and NOT affect the function of the protein 2. This would be a nonsense mutation and affect the function of the protein 3. This would be a missense mutation and affect the function of the protein 4. This would be a silent mutation and NOT affect the function of the protein...
Based on the genetic code chart below, which of the following would be the result of this single base-pair substitution?
The diagram below shows an mRNA molecule that encodes a protein with 202 amino acids. The start and stop codons are highlighted, and a portion of the nucleotide sequence in the early part of the molecule is shown in detail. At position 35, a single base-pair substitution in the DNA has changed that would have been a uracil (U) in the mRNA to an adenine (A). Based on the genetic code chart below, which of the following would be the...
explain how polygenic inheritance differs from that resulting from the action of a single pair of...
explain how polygenic inheritance differs from that resulting from the action of a single pair of alleles. pick a specific way and discuss it. Also, add citation at the end.
Refactor the following classes so they are both derived from a base class called Person. Write...
Refactor the following classes so they are both derived from a base class called Person. Write the code for the new base class as well. Try to avoid repeating code as much as possible. Write the classes so that any common methods can be invoked through a pointer or reference to the base class. #include <string> #include <cmath> using namespace std; class Student { private: string name;    int age;    int studyYear; public:    Student(string,int,int); void study();    void...
What happens when one base pair of DNA is lost from the coding region of a...
What happens when one base pair of DNA is lost from the coding region of a gene because of mutation? First explain how this would affect the mRNA sequence, and second, explain how this would alter the amino acid of the protein that is encoded.
Three different brands of tires were compared for wear characteristics. From each brand of tire, six...
Three different brands of tires were compared for wear characteristics. From each brand of tire, six (6) tires were randomly selected and subjected to standard wear-testing procedures. The average mileage obtained for each brand of tire and sample variances (both in 1,000 miles) are shown below. Brand A Brand B Brand C Average Mileage 37 38 33 Sample variance 3 4 2             At 95% confidence, using both critical value and P-value to test to see if there is a...
ADVERTISEMENT
ADVERTISEMENT
ADVERTISEMENT