Provide a reason why a ligand should not bind covalently to a receptor.

Expert Solution

Covalent bonding is a very tight bonding with involves sharing of electrons and other types of bonding, non covalent bonding, are loose type of bonding which involves transfer of electrons.

So, if a ligand will bind to its receptor very tightly by covalent bonding, then either the ligand will not leave the receptor or it will take a lot of ATP molecules to get both of them was associated. In this case, the receptor will not become free easily and will not be able to bind to another molecule of ligand and therefore the downstream cascade of cell signalling processes will not take place. In such a situation, the alteration in cell processes by binding to any external ligand will take a lot of time and energy.

Therefore it is very important that the interaction between receptor and ligand is not very tight. It should be loose and a so that the ligand comes out of the receptor easily and it should be tight enough in order to initiate the downstream process.

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gladiator answered 2 years ago

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