Describe the series of events that occurs when a ligand binds to a receptor tyrosine kinase...

Describe the series of events that occurs when a ligand binds to a receptor tyrosine kinase during cellular signalling, and what occurs once the ligand is removed?

Describe the series of events that occurs before and after a ligand binds to a G protein coupled receptor during cellular signalling?

Solutions

Expert Solution

TKR (Tyrosine Kinase Receptor) is very important signalling molecule for downstream response and any abnormality in this pathway can cause serious consequences including diseases like cancer. Detail of this receptor is given below:

GPCR is another important receptor and also known as seven transmembrane receptor and it is described through a flow diagram and given below:

gladiator answered 1 year ago

Next > < Previous

Related Solutions

Receptor Tyrosine Kinases and Ras a. Describe the events that occur upon ligand binding to receptor...

Receptor Tyrosine Kinases and Ras a. Describe the events that occur upon ligand binding to receptor kinase receptors. b. Describe the similarities and differences in the cycling of Gs and Ras between the active and inactive forms. c. Describe the kinase cascade that transmits signals down from activated Ras.

What is a tyrosine kinase receptor (RTK)? Describe how this type of receptor works. Once activated,...

What is a tyrosine kinase receptor (RTK)? Describe how this type of receptor works. Once activated, what kind of enzyme is needed to deactivate the receptor? Explain

A receptor tyrosine kinase (RTK) has a non-functioning kinase domain

A receptor tyrosine kinase (RTK) has a non-functioning kinase domain Enhanced or Reduced A G-protein whose α-subunit has a higher than normal binding affinity for GTP and a normal binding affinity for GDP. Enhanced or Reduced Protein Kinase A whose regulatory subunits cannot bind cAMP Enhanced or Reduced IP3 cannot bind to ER-calcium channels Enhanced or Reduced Notch cannot be cleaved following binding to Delta Enhanced or Reduced Sodium orthovanadate, a phosphatase inhibitor, is added to cells that have...

1. The insulin receptor is: A. a metabolite receptor B. a receptor tyrosine kinase. C. a...

1. The insulin receptor is: A. a metabolite receptor B. a receptor tyrosine kinase. C. a GPCR D. a gasotransmitter E. a second messenger 2. Which of the following reactions requires a Vitamin B12 cofactor? A. beta-oxidation of 18:0 B. beta-oxidation of (18:1 delta 9) C. beta-oxidation of (16:2 delta 9 delta 12) D. complete oxidation of (19:0) E. all of these require Vitamin B12 3. Metabolite receptors bind to ___________________. A. second messengers B. DNA C. GPCRs D. Protein...

Binding of a signal to the receptor tyrosine kinase DIRECTLY, initially causes:

Why would overexpression of RTK (Receptor Tyrosine Kinase) lead to an oncogenic phenotype (describe the mechanism)?

Q. Draw a map of how the Receptor Tyrosine Kinase (RTK) links to the Ras-Map Kinase...

Q. Draw a map of how the Receptor Tyrosine Kinase (RTK) links to the Ras-Map Kinase Pathway versus the PI3K/AKT Pathway. Be sure to include where these pathways end up - the cellular response. Keep in mind that Ras-Map and PI3K/AKT are at the top of the pathway. I want you to pick a direction coming down. Your textbook can help get you started, but you will have to research/Google where these pathways go. While there are many possible directions,...

What does binding of its ligand do to a receptor kinase?

Give one example of how you would assay for overexpression of RTK (Receptor Tyrosine Kinase). Would...

Give one example of how you would assay for overexpression of RTK (Receptor Tyrosine Kinase). Would it be an immune complex kinase assay then determine if it's a tyrosine kinase? I'm not sure.

Explain the cell signaling pathway which involves membrane receptor (tyrosine kinase receptors and G protein-coupled receptors)....

Explain the cell signaling pathway which involves membrane receptor (tyrosine kinase receptors and G protein-coupled receptors). Use ONE (1) specific example to explain each reception pathway. The details of the summary should be concise and informative. The length of the summary for each type of membrane receptor should be less than 200 words.

Subjects