In: Biology
Dopamine (DA) |
Norepinephrine (NE) |
Serotonin (5-HT) |
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Yes NT are used in PNS
Yes NT are used in CNS
Cell bodies are located in gray matter of brain and spinal cord, cell bodies are located in dorsal ganglia of spinal cord and in neuron cell is the first part (Anterior) part of neuron.
Axon projected away from the cyton or cell body. Axon is long cylindrical process of neuron.
NT are synthesized in the axon terminal
Amino acids are the precursor of various NT such as Dopamine can be synthesized from phenylalanine indirectly or from tyrosine directly.
NT are stored in small vesicles in the axon terminal.
Nerve impulse reaches to the presynaptic terminal results in the opening of Calcium ion channel and entrty of calcium ions mobilize the the small NT filled vesicles towards presynaptic membrane and finnaly the NT releases in the synaptic gap
In eukaryotic cells both ionotropic and metabotropic receptor is present made up of glycoproteins and mostly embeded in the post synaptic membrame (some in presynaptic membrane also) and selectively bind neurotransmitters.
Receptors binds to the NT which results in the influx of ions by opening of ion channels and propagate the electrical signal or nerve impulse.
NT can be reuptake or be broken down by the enzyme such as acetylcholine is degraded by acetylcholinesterase into acetate and choline.
Acetylcholine is degraded by acetylcholinesterase into acetate and choline.
NT are inhibitory such as glycine and excitatory such as serotonin.
clinical disorders such as Parkinson's disease caused by the destruction of dopamine secreting par compacta
part of basal nucleus called substantia nigra.
Dopamine is responsible for sleep, mood, pleasure etc.
Norepinephrine is called as figh and flight hormone released during emergency.
Serotoni is responsible for anxiety, happiness and mood.
Dopamine |
Norepinephrine |
Serotonin (5-HT) |
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1 |
Yes |
Yes |
Yes |
2 |
yes |
Yes |
Yes |
13 |
Deficiency of dopamine is linked to depression, schizophrenia |
Low levels can causes lethargy, depression, lack of concentration etc. |
High levels causes happiness and low levels causes depression. |
Please note:- Dear student earlier your question was not displayed me completely so I answered in differently.