Explain the regulation of gene expression in eukaryotic
cells.
Discuss mechanisms by which gene expression may be
altered.
How do these alterations induce cancer-causing mutations in
cell DNA?
Explain how cancer is formed.
Describe genetic changes found in cancer cells and how these
changes lead to alterations in cell behavior.
Determine whether proteome data can be utilized in genetic
disorder diagnosis.
Relate the Human Genome Project data to the analysis of cancer
genes.
Name and describe one method a eukaryotic cell can regulate
transcription of a gene
Name and describe one method a eukaryotic cell can regulate
translation of a gene
Name and describe one method a eukaryotic cell can regulate
expression of a gene at any level
You are working on a research project involving a novel
transcription factor that regulates gene expression specifically in
muscle cells (called MUSC1). You have already done an experiment
where you showed that the addition of MUSC1 to muscle cells in
culture greatly increased the expression of both actin and myosin
(contractile proteins in muscle cells). Answer the following
questions below:
Is MUSC1 a general or regulatory transcription factor? Explain
your answer.
What two specific components would you expect MUSC1 to...
Place the steps in their proper order on the figure to complete the summary of gene expression in a eukaryotic cell, Place your cursor on the boxes for hints.
1. Eukaryotic transcription factors control gene expression in a
combinatorial manner. a) With the aid of a diagram, briefly discuss
this statement. b) Provide an example of how combinatorial
regulation of gene expression is involved in the development of
higher organisms.